EC Number   |
Cofactor |
Reference |
|---|
    4.1.1.25 | pyridoxal 5'-phosphate |
- |
4194, 653443, 679387, 681795, 692429, 693429, 694762, 716077, 728747, 747444, 747848, 749003, 749056 |
| 4.1.1.25 | pyridoxal 5'-phosphate |
activates, activity is dependent on cofactor |
651348 |
| 4.1.1.25 | pyridoxal 5'-phosphate |
coenzyme dependence |
651361 |
| 4.1.1.25 | pyridoxal 5'-phosphate |
cofactor |
4193 |
| 4.1.1.25 | pyridoxal 5'-phosphate |
cofactor, presence inhibits decarboxylation of DOPA by 50-60% |
653346 |
| 4.1.1.25 | pyridoxal 5'-phosphate |
dependent on |
661251, 705841 |
| 4.1.1.25 | pyridoxal 5'-phosphate |
functional group |
4194 |
| 4.1.1.25 | pyridoxal 5'-phosphate |
PLP, binding structure, overview. The cofactor is covalently attached to the epsilon-amino group of K321 to form an internal aldimine via a Schiff-base interaction. The protonated pyridine nitrogen of PLP forms a pair of salt bridges to the carboxyl group of D289. The PLP pyridine ring is anchored by the methyl group of A291 and the imidazole ring of H205. The O3 atom of the pyridine ring of PLP seems to interact with T264 adjacent water molecules. The phosphate moiety of PLP is stabilized by a number of interactions with T169, C170, N318 of one subunit, and R373 of the other subunit |
747859 |
| 4.1.1.25 | pyridoxal 5'-phosphate |
PLP, dependent on |
749322 |
| 4.1.1.25 | pyridoxal 5'-phosphate |
requirement |
651371 |
