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EC Number	Substrates	Commentary Substrates	Organism	Products	Commentary (Products)	Reversibility
2.1.1.117	S-Adenosyl-L-methionine + norlaudanosoline	2% of the activity relative to (S)-scoulerine	Coptis japonica	?	-	?
2.1.1.117	S-Adenosyl-L-methionine + norreticuline	9% of the activity relative to (S)-scoulerine	Coptis japonica	?	-	?
2.1.1.117	S-Adenosyl-L-methionine + (S)-scoulerine	-	Coptis teeta	S-Adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine	-	?
2.1.1.117	more	enzyme is a scoulerine-9-O-methyltransferase for the biosynthesis of chelerythrine in California poppy, it produces 7-O-methylated, 3'-O-methylated and dual O-methylated products from reticuline and norreticuline, and 9-O-methylated tetrahydrocolumbamine, 2-O-methylscoulerine and tetrahydropalmatine from scoulerine	Eschscholzia californica subsp. californica	?	-	-
2.1.1.117	S-adenosyl-L-methionine + (S)-norreticuline	-	Eschscholzia californica subsp. californica	S-adenosyl-L-homocysteine + norcodamine + norlaudanine	-	?
2.1.1.117	S-adenosyl-L-methionine + (S)-reticuline	-	Eschscholzia californica subsp. californica	S-adenosyl-L-homocysteine + codamine + laudanine	-	?
2.1.1.117	S-adenosyl-L-methionine + (S)-scoulerine	-	Eschscholzia californica subsp. californica	S-adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine + 2-O-methylscoulerine + tetrahydropalmatine	-	?
2.1.1.117	S-Adenosyl-L-methionine + (S)-scoulerine	-	Papaver somniferum	S-Adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine	-	?
2.1.1.117	more	enzyme catalyzes O-methylation at C-9 and C-2, and O-methylation events occur first at C-9 and then at C-2	Stephania intermedia	?	-	-
2.1.1.117	S-adenosyl-L-homocysteine + (S)-tetrahydropalmatrubine	-	Stephania intermedia	S-adenosyl-L-homocysteine + (S)-tetrahydropalmatine	-	?

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Release 2023.1 (January 2023)