EC Number   |
General Information |
Reference |
|---|
   3.1.6.2 | malfunction |
deletion of the STS gene is associated with atypical X-linked ichthyosis |
704081 |
| 3.1.6.2 | malfunction |
hormone-dependent breast cancer might be effectively treated by dual inhibition of aromatase and steroid sulfatase |
714906 |
| 3.1.6.2 | malfunction |
steroid sulfatase/estrogen sulfotransferase status is associated with intratumoral estrogen level in the colon carcinoma, and steroid sulfatase-negative/estrogen sulfotransferase-positive colon carcinoma patients have longer survival. STS mRNA expression is higher in breast carcinoma tissues than that in normal breast tissues, and it is significantly associated with the breast carcinoma progression and poor clinical outcome of the patients |
716213 |
| 3.1.6.2 | malfunction |
STS deficiency is an X-linked recessive, generally mild chronic disorder that presents clinically in the first year of life as scaly skin (ichthyosis) |
706472 |
| 3.1.6.2 | metabolism |
conversion of estrone sulfate to estrone is a non-aromatase-based route to estrone and estradiol in postmenopausal women |
714821 |
| 3.1.6.2 | metabolism |
relevance and interplay between aromatase, steroid sulfatase, organic anion transporting polypeptide B, and 17beta-hydroxysteroid dehydrogenase type 1 to facilitate local synthesis of estrogenic steroids within breast and other tissues, pathways of local synthesis of estrogenic steroids in neoplastic breast tissue, overview |
716214 |
| 3.1.6.2 | more |
active site residues are D35, D36, FGS75, R79, K134, H136, H290, D342, Q343, and K368 |
714906 |
| 3.1.6.2 | physiological function |
activation of steroid sulfatase pathway due to increment in steroid sulfatase and/or decrement in estrogen sulfotransferase expressions plays important role in their estrogen-dependent growth |
716213 |
| 3.1.6.2 | physiological function |
both expression and activity of STS increase in response to a decidualisation stimulus. Inhibition of STS activity disrupts bioavailability of estrogens and inhibits decidualisation responses consistent with stromal utilisation of sulfated steroids as precursors to active hormones during decidualisation |
751352 |
| 3.1.6.2 | physiological function |
steroid sulfatase controls the levels of 3-hydroxysteroids available from circulating steroid sulfates in several normal and malignant tissues |
714906 |
