Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
estrone sulfate + H2O | Homo sapiens | estrone is locally produced from circulating inactive estrone sulfate by steroid sulfatase | estrone + sulfate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast carcinoma cell | steroid sulfatase enzyme activity is detected in the great majority of breast carcinomas | Homo sapiens | - |
carcinoma cell | - |
Homo sapiens | - |
colonic cancer cell | - |
Homo sapiens | - |
endometrial cancer cell | - |
Homo sapiens | - |
ovary cancer cell | - |
Homo sapiens | - |
prostate gland cancer cell | - |
Homo sapiens | - |
uterine endometrial carcinoma cell | - |
Homo sapiens | - |
uterine endometrium | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
estrone sulfate + H2O | - |
Homo sapiens | estrone + sulfate | - |
? | |
estrone sulfate + H2O | estrone is locally produced from circulating inactive estrone sulfate by steroid sulfatase | Homo sapiens | estrone + sulfate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
steroid sulfatase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | steroid sulfatase expression is upregulated in breast carcinomas | up |
General Information | Comment | Organism |
---|---|---|
malfunction | steroid sulfatase/estrogen sulfotransferase status is associated with intratumoral estrogen level in the colon carcinoma, and steroid sulfatase-negative/estrogen sulfotransferase-positive colon carcinoma patients have longer survival. STS mRNA expression is higher in breast carcinoma tissues than that in normal breast tissues, and it is significantly associated with the breast carcinoma progression and poor clinical outcome of the patients | Homo sapiens |
physiological function | activation of steroid sulfatase pathway due to increment in steroid sulfatase and/or decrement in estrogen sulfotransferase expressions plays important role in their estrogen-dependent growth | Homo sapiens |