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Literature summary for 3.1.6.2 extracted from

  • Shah, K.; Cartledge, T.; Ahmed, S.
    Estrone sulfatase, a target enzyme in the treatment of hormone-dependent breast cancer (2010), Drugs Future, 35, 729-745.
No PubMed abstract available

Application

Application Comment Organism
medicine estrone sulfatase is a target enzyme in the treatment of hormone-dependent breast cancer Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information design and synthesis of steroidal and nonsteroidal enzyme inhibitors as sulfamate derivatives and nonsulfamate derivatives, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
estrone sulfate + H2O Homo sapiens
-
estrone + sulfate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell hormone-dependent Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
estrone sulfate + H2O
-
Homo sapiens estrone + sulfate
-
?

Synonyms

Synonyms Comment Organism
estrone sulfatase
-
Homo sapiens

General Information

General Information Comment Organism
metabolism conversion of estrone sulfate to estrone is a non-aromatase-based route to estrone and estradiol in postmenopausal women Homo sapiens