EC Number   |
General Information |
Reference |
|---|
   3.4.22.53 | physiological function |
calpain 2 plays a role in the generation of the low molecular weight-androgen receptor in CWR22-R1 cells |
709126 |
| 3.4.22.53 | physiological function |
calpain 2 promotes proliferation of cancer cells through Akt-FoxO-p27Kip1 signaling |
732050 |
| 3.4.22.53 | physiological function |
calpain 2 proteolysis of mAbp1 negatively regulates dorsal ruffle formation |
709873 |
| 3.4.22.53 | metabolism |
calpain 2 regulates endothelial nitric oxide synthase phosphorylation during cord formation by lymphatic endothelial cells on Matrigel |
731892 |
| 3.4.22.53 | physiological function |
calpain 2-mediated proteolysis of focal adhesion kinase regulates adhesion dynamics in motile cells |
709087 |
| 3.4.22.53 | malfunction |
calpain inhibition blocks the increased colonic epithelial cell invasion caused by NM IIA knockdown |
707044 |
| 3.4.22.53 | malfunction |
calpain inhibition favors differentiation of neuronal stem cells. Calpain 2 silencing elicits decreased levels of glial fibrillary acidic protein |
732688 |
| 3.4.22.53 | physiological function |
calpain-1 and calpain-2 play opposite functions in both synaptic plasticity/learning and memory and neuroprotection/neurodegeneration. Calpain-1 activation is necessary for certain forms of synaptic plasticity and learning and memory, while calpain-2 activation during a brief consolidation period limits the extent of plasticity/learning. Calpain-1 is neuroprotective, while calpain-2 is neurodegenerative. Calpain-2 activation, through the selective degradation of phosphatase PTEN, is linked to the regulation of mTOR-mediated local protein synthesis |
755619 |
| 3.4.22.53 | physiological function |
calpain-1 and calpain-2 play opposite roles in retinal ganglion cell death induced by acute intraocular pressure elevation. Calpain-1 activity supports survival of retinal ganglion cell after intraocular pressure elevation. Calpain-2 activity promotes cell death of retinal ganglion cells after intraocular pressure elevation. Calpain-2 activation cleaves striatal-enriched protein tyrosine phosphatase and activates STEP-mediated pro-death pathway in retinal ganglion cells after intraocular pressure elevation |
754896 |
| 3.4.22.53 | physiological function |
calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes |
717806 |
