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Literature summary for 3.4.22.53 extracted from
- Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK) (2010), J. Biol. Chem., 285, 11418-11426.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| N-acetyl-Leu-Leu-Met | - |
Rattus norvegicus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| focal adhesion kinase + H2O | the preferred calpain cleavage site is between the two C-terminal proline-rich regions after Ser-745 | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| calpain 2 | - |
Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | calpain 2-mediated proteolysis of focal adhesion kinase regulates adhesion dynamics in motile cells | Rattus norvegicus |
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Release 2023.1 (January 2023)
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