EC Number   |
General Information |
Reference  |
|---|
   3.2.2.6 | evolution |
the CD38-cADPR signaling system is conserved during vertebrate evolution, phylogenetic tree |
732501 |
| 3.2.2.6 | physiological function |
the enzyme is CD38-cADPR signaling system in frog cells |
732501 |
| 3.2.2.6 | more |
invariant glutamate 218 identified is the catalytic residue of the enzyme, Structure homology modelling, overview |
732691 |
| 3.2.2.6 | physiological function |
senescent cells do not have high expression of CD38. The senescent associated secretory phenotype factors secreted by senescent cells induce CD38 mRNA and protein expression and increase CD38-NADase activity in non-senescent cells such as endothelial cells or bone marrow derived macrophages |
749830 |
| 3.2.2.6 | physiological function |
in cultured macrophages, lipopolysaccharide LPS can upregulate CD38 expression in time- and dose-dependent manner. Knocking down or blockade of CD38 in macrophages inhibits LPS-induced macrophage M1 polarization accompanied by diminished NF-kappaB signaling activation. In a mouse model with LPS-induced acute kidney injury, blocking CD38 with quercetin significantly relieves kidney dysfunction, kidney pathological changes as well as inflammatory cell accumulation |
750282 |
