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Literature summary for 3.2.2.6 extracted from

  • Ikeda, T.; Takasawa, S.; Noguchi, N.; Nata, K.; Yamauchi, A.; Takahashi, I.; Yoshikawa, T.; Sugawara, A.; Yonekura, H.; Okamoto, H.
    Identification of a major enzyme for the synthesis and hydrolysis of cyclic ADP-ribose in amphibian cells and evolutional conservation of the enzyme from human to invertebrate (2012), Mol. Cell. Biochem., 366, 69-80.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene cd38, eight exons, DNA and amino acid sequence determination and analysis, sequence comparison to the human enzyme, phylogenetic tree, expression in COS-7 cells Xenopus laevis

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane most frog enzyme (81%) is distributed in the membrane fraction (5% in mitochondrial fraction and 14% in microsomal fraction) Xenopus laevis 16020
-
microsome
-
Xenopus laevis
-
-
mitochondrion mitochondrial membrane Xenopus laevis 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
28970
-
x * 45000, SDS-PAGE, x * 28970, sequence calculation Xenopus laevis
45000
-
x * 45000, SDS-PAGE, x * 28970, sequence calculation Xenopus laevis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cyclic ADP-ribose + H2O Xenopus laevis
-
ADP-D-ribose
-
?
additional information Xenopus laevis frog CD38 enzyme shows NAD+ glycohydrolase, ADP-ribosyl cyclase, and cyclic ADP-ribosyl hydrolase activities ?
-
?
NAD+ Xenopus laevis
-
cyclic ADP-ribose + nicotinamide
-
?
NAD+ + H2O Xenopus laevis overall reaction ADP-D-ribose + nicotinamide
-
?

Organism

Organism UniProt Comment Textmining
Xenopus laevis H7C831 gene cd38
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Xenopus laevis

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Xenopus laevis
-
liver
-
Xenopus laevis
-
additional information the enzyme is ubiquitously expressed in various tissues Xenopus laevis
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0604
-
NAD+-glycohydrolase activityin crude cell extract, pH 7.4, 37°C Xenopus laevis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cyclic ADP-ribose + H2O
-
Xenopus laevis ADP-D-ribose
-
?
additional information frog CD38 enzyme shows NAD+ glycohydrolase, ADP-ribosyl cyclase, and cyclic ADP-ribosyl hydrolase activities Xenopus laevis ?
-
?
NAD+
-
Xenopus laevis cyclic ADP-ribose + nicotinamide
-
?
NAD+ + H2O overall reaction Xenopus laevis ADP-D-ribose + nicotinamide
-
?

Subunits

Subunits Comment Organism
? x * 45000, SDS-PAGE, x * 28970, sequence calculation Xenopus laevis

Synonyms

Synonyms Comment Organism
CD38
-
Xenopus laevis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Xenopus laevis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Xenopus laevis

General Information

General Information Comment Organism
evolution the CD38-cADPR signaling system is conserved during vertebrate evolution, phylogenetic tree Xenopus laevis
physiological function the enzyme is CD38-cADPR signaling system in frog cells Xenopus laevis