EC Number   |
General Information |
Reference |
|---|
    1.1.1.37 | more |
sequence-similarity networks analysis |
-, 748018 |
| 1.1.1.37 | more |
the active loop on cMDH closing after sequential binding of NADH binding to the enzyme followed by the substrate |
740166 |
| 1.1.1.37 | physiological function |
besides its function in malate synthesis, MDH is responsible for the exchange of reducing equivalents between metabolic pathways in distinct cell compartments |
-, 723059 |
| 1.1.1.37 | physiological function |
cyMDH is an enzyme crucial for malate synthesis in the cytosol. Involvement of MdcyMDH directly in malate synthesis and indirectly in malate accumulation through the regulation of genes/enzymes associated with malate degradation and transportation, gluconeogenesis and the tricarboxylic acid cycle. |
712865 |
| 1.1.1.37 | physiological function |
cyMDH is an enzyme crucial for malic acid synthesis in the cytosol. Role of the apple cyMDH gene in growth and tolerance to cold and salt stresses. cyMDH was sensitive to cold and salt stresses. cyMDH overexpression favourably contributes to cell and plant growth and confers stress tolerance in the apple |
713301 |
| 1.1.1.37 | physiological function |
cytosolic NAD-dependent malate dehydrogenase is an enzyme crucial for malate synthesis in the cytosol |
712865 |
| 1.1.1.37 | physiological function |
in illuminated chloroplasts, one mechanism involved in reduction-oxidation (redox) homeostasis is the malate-oxaloacetate shuttle. Excess electrons from photosynthetic electron transport in the form of nicotinamide adenine dinucleotide phosphate, reduced are used by NADP-dependent malate dehydrogenase (MDH), EC 1.1.1.82, to reduce oxaloacetate to malate, thus regenerating the electron acceptor NADP. NADP-MDH is a strictly redox-regulated, light-activated enzyme that is inactive in the dark. In the dark or in nonphotosynthetic tissues, the malate-oxaloacetate shuttle was proposed to be mediated by the constitutively active plastidial NAD-specific MDH isoform (pdNAD-MDH), but evidence is scarce. Critical role of pdNAD-MDH in Arabidopsis thaliana plants. Distinct roles for NAD- and NADP-linked redox homeostasis. pdNAD-MDH influences chloroplast ultrastructure and photosynthetic metabolism |
741200 |
| 1.1.1.37 | physiological function |
MDH is an energy-supplying enzyme, that catalyzes the interconversion of malate and oxaloacetate and plays crucial roles in several metabolic pathways including the citric acid cycle. The phosphorylation of enzyme MDH by serine/threonine protein kinases negatively regulates its activity |
-, 741234 |
| 1.1.1.37 | physiological function |
MDH is an essential enzyme in the tricarboxylic acid cycle. Inhibition of mMDH activity affects cell energy production, probably leading to the inhibition of proliferation. Inhibition of mMDH activity by DIF-1 and 2-MIDIF-1 can be one of the mechanisms to induce anti-proliferative effects, independent of the inhibition of the Wnt/beta-catenin signaling pathway |
712850 |
| 1.1.1.37 | physiological function |
MDH1 plays a critical role in the cellular senescence of human fibroblasts. MDH1 is the major regulator of the cofactor NAD, the loss of which induces cellular senescence |
723540 |
