Information on EC 1.1.1.37 - malate dehydrogenase

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The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

EC NUMBER
COMMENTARY hide
1.1.1.37
-
RECOMMENDED NAME
GeneOntology No.
malate dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(S)-malate + NAD+ = oxaloacetate + NADH + H+
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
aspartate and asparagine metabolism
-
-
C4 and CAM-carbon fixation
-
-
citric acid cycle
-
-
Citrate cycle (TCA cycle)
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Cysteine and methionine metabolism
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Pyruvate metabolism
-
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Glyoxylate and dicarboxylate metabolism
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Methane metabolism
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Carbon fixation in photosynthetic organisms
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Carbon fixation pathways in prokaryotes
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Metabolic pathways
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Biosynthesis of secondary metabolites
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Microbial metabolism in diverse environments
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Biosynthesis of antibiotics
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L-aspartate degradation II
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superpathway of glyoxylate cycle and fatty acid degradation
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anaerobic energy metabolism (invertebrates, cytosol)
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mixed acid fermentation
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gluconeogenesis I
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TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)
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partial TCA cycle (obligate autotrophs)
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reductive TCA cycle I
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TCA cycle IV (2-oxoglutarate decarboxylase)
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incomplete reductive TCA cycle
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C4 photosynthetic carbon assimilation cycle, NAD-ME type
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methylaspartate cycle
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TCA cycle I (prokaryotic)
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TCA cycle III (animals)
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gluconeogenesis III
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pyruvate fermentation to propanoate I
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reductive TCA cycle II
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TCA cycle II (plants and fungi)
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formaldehyde assimilation I (serine pathway)
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glyoxylate cycle
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SYSTEMATIC NAME
IUBMB Comments
(S)-malate:NAD+ oxidoreductase
Also oxidizes some other 2-hydroxydicarboxylic acids.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-64-3
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Uniprot
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
pineapple, cv. Havaiano
-
-
Manually annotated by BRENDA team
sea urchin
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain B60
-
-
Manually annotated by BRENDA team
strain B60
-
-
Manually annotated by BRENDA team
strain D-402
-
-
Manually annotated by BRENDA team
strain D-402
-
-
Manually annotated by BRENDA team
3I1B-143 bacteroids
-
-
Manually annotated by BRENDA team
two isozymes
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Bryophyllum calycinum
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
watermelon
-
-
Manually annotated by BRENDA team
Citrus sp.
lemon fruit
-
-
Manually annotated by BRENDA team
Coccochloris peniocystis
no. 1548
-
-
Manually annotated by BRENDA team
Coccochloris peniocystis 1548
no. 1548
-
-
Manually annotated by BRENDA team
strain NC4 (ATCC 24697)
-
-
Manually annotated by BRENDA team
strain NC4 (ATCC 24697)
-
-
Manually annotated by BRENDA team
Oregon K
-
-
Manually annotated by BRENDA team
Texmelucan
-
-
Manually annotated by BRENDA team
strain MG1655, gene mdh
UniProt
Manually annotated by BRENDA team
SM-ZK
-
-
Manually annotated by BRENDA team
brown shrimp
-
-
Manually annotated by BRENDA team
Duch. cv. Elsanta
-
-
Manually annotated by BRENDA team
teleost
-
-
Manually annotated by BRENDA team
soybean, Williams 79 cultivar
-
-
Manually annotated by BRENDA team
isoforms A1, A2 and B
-
-
Manually annotated by BRENDA team
marine snail
-
-
Manually annotated by BRENDA team
N.C.I.B. 10486
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
Uniprot
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
Uniprot
Manually annotated by BRENDA team
-
Uniprot
Manually annotated by BRENDA team
-
Uniprot
Manually annotated by BRENDA team
-
Uniprot
Manually annotated by BRENDA team
-
Uniprot
Manually annotated by BRENDA team
strain D-405
-
-
Manually annotated by BRENDA team
strain D-405
-
-
Manually annotated by BRENDA team
strain GPI
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain 2D2
SwissProt
Manually annotated by BRENDA team
strain 5710
-
-
Manually annotated by BRENDA team
mouse
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
marine diatom
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-
Manually annotated by BRENDA team
no activity in Chromatium sp.
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-
Manually annotated by BRENDA team
no activity in Mycobacterium fortuitum
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-
Manually annotated by BRENDA team
no activity in Mycobacterium smegmatis
-
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-
Manually annotated by BRENDA team
no activity in Mycobacterium smegmatis 607
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-
Manually annotated by BRENDA team
cactus
-
-
Manually annotated by BRENDA team
lamb
-
-
Manually annotated by BRENDA team
strain E
-
-
Manually annotated by BRENDA team
pea
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Manually annotated by BRENDA team
inhabiting the mantle cavity of host Pinna nobilis
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Manually annotated by BRENDA team
; a hyperthermophilic archaeon, strain DSM 4184
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Manually annotated by BRENDA team
Sprague-Dawley
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-
Manually annotated by BRENDA team
strain 37b4
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-
Manually annotated by BRENDA team
strain 2R
-
-
Manually annotated by BRENDA team
strain 6770
-
-
Manually annotated by BRENDA team
strain 6770
-
-
Manually annotated by BRENDA team
strain EY33
-
-
Manually annotated by BRENDA team
strain f8pt
-
-
Manually annotated by BRENDA team
strain 1.1.1
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-
Manually annotated by BRENDA team
strain 1.1.1
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Manually annotated by BRENDA team
castor bean
-
-
Manually annotated by BRENDA team
DSM 13855
-
-
Manually annotated by BRENDA team
potato
-
-
Manually annotated by BRENDA team
gene mdh
Uniprot
Manually annotated by BRENDA team
strain 6803 CF
-
-
Manually annotated by BRENDA team
strain 6803 CF
-
-
Manually annotated by BRENDA team
DSM 10017
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-
Manually annotated by BRENDA team
N.C.I.B. 11185
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-
Manually annotated by BRENDA team
N.C.I.B. 11185
-
-
Manually annotated by BRENDA team
strain B
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-
Manually annotated by BRENDA team
strain YT-1
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-
Manually annotated by BRENDA team
strain TV 10-02, strain Tv-1961, strain Tv-1973
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-
Manually annotated by BRENDA team
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Uniprot
Manually annotated by BRENDA team
a syntropic propionate-oxidizing strain
-
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Manually annotated by BRENDA team
a syntropic propionate-oxidizing strain
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Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
black gram, mung bean
-
-
Manually annotated by BRENDA team
Viola sp.
-
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-
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
-
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-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2S,3S)-tartrate + NAD+
? + NADH
show the reaction diagram
(S)-2-hydroxyglutarate + NAD+
2-oxoglutarate + NADH + H+
show the reaction diagram
-
oxidized at an extremely slow rate, less than 0.001% of the rate of L-malate oxidation
-
-
r
(S)-malate + 3-acetylpyridine-adenine dinucleotide
oxaloacetate + reduced 3-acetylpyridine-adenine dinucleotide + H+
show the reaction diagram
-
can also use 3-acetylpyridine-adenine as cofactor
-
-
r
(S)-malate + acetylpyridine adenine dinucleotide
oxaloacetate + reduced acetylpyridine adenine dinucleotide
show the reaction diagram
-
-
-
?
(S)-malate + NAD(P)+
oxaloacetate + NAD(P)H
show the reaction diagram
-
-
-
-
r
(S)-malate + NAD+
acetate + CO2 + H2 + NADH
show the reaction diagram
-
-
-
?
(S)-malate + NAD+
oxaloacetate + NADH + H+
show the reaction diagram
(S)-malate + NADP+
oxaloacetate + NADPH + H+
show the reaction diagram
1,4,5,6-tetrahydronicotinamide + L-malate
?
show the reaction diagram
-
-
-
-
?
2-oxobutyrate + NADH
2-hydroxybutyrate + NAD+
show the reaction diagram
-
-
-
-
?
2-oxoglutarate + NADH + H+
2-hydroxyglutarate + NAD+
show the reaction diagram
about 10% of the activity with oxaloacetate at pH 6.8 and at pH 8.2
-
-
?
3-acetylpyridine adenine dinucleotide + L-malate
?
show the reaction diagram
-
-
-
-
?
3-bromopyruvate + NADH
3-bromo-2-hydroxypropanoate + NAD+
show the reaction diagram
about 10% of the activity with oxaloacetate at pH 6.8
-
-
?
alpha-keto-malonate + NADH
? + NAD+
show the reaction diagram
alpha-ketoisovalerate + NADH
2-hydroxyisovalerate + NAD+
show the reaction diagram
about 10% of the activity with oxaloacetate at pH 8.2
-
-
?
alpha-ketomalonate + NADH
?
show the reaction diagram
-
-
-
?
citrate + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
hydroxymalonate + NAD+
? + NADH
show the reaction diagram
L-lactate + NAD+
? + NADH
show the reaction diagram
-
cMDH less catalytically efficient than against its natural substrate malate
-
-
?
malate + NAD+
oxaloacetate + NADH
show the reaction diagram
meso-tartrate + NAD+
? + NADH
show the reaction diagram
nicotinamide 1-N6-ethenoadenine dinucleotide + L-malate
?
show the reaction diagram
-
-
-
-
?
nicotinamide hypoxanthine dinucleotide + L-malate
?
show the reaction diagram
-
-
-
-
?
oxaloacetate + NADH
(S)-malate + NAD+
show the reaction diagram
oxaloacetate + NADH
L-malate + NAD+
show the reaction diagram
oxaloacetate + NADH + H+
(S)-malate + NAD+
show the reaction diagram
oxaloglycolate + NAD+
? + NADH
show the reaction diagram
-
-
-
-
r
p-hydroxyphenylpyruvate + NADH + H+
2-hydroxy-3-(4-hydroxyphenyl)propanoate
show the reaction diagram
-
-
-
?
phenylpyruvate + NADH
2-hydroxy-3-phenylpropanoate + NAD+
show the reaction diagram
about 30% of the activity with oxaloacetate at pH 8.2
-
-
?
phenylpyruvate + NADH + H+
2-hydroxy-3-phenylpropanoate + NAD+
show the reaction diagram
-
-
-
?
pyridine 3-aldehyde adenine dinucleotide + L-malate
?
show the reaction diagram
-
-
-
-
?
pyruvate + NAD+
? + NADH
show the reaction diagram
-
cMDH less catalytically efficient than against its natural substrate malate
-
-
?
pyruvate + NADH
2-hydroxypropanoate + NAD+
show the reaction diagram
about 25% of the activity with oxaloacetate at pH 8.2
-
-
?
pyruvate + NADH + H+
(S)-lactate + NAD+
show the reaction diagram
thionicotinamide adenine dinucleotide + L-malate
?
show the reaction diagram
-
-
-
-
?
additional information
?
-