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Information on EC 1.1.1.82 - malate dehydrogenase (NADP+)
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EC Tree
1.1.1.82 malate dehydrogenase (NADP+)IUBMB Comments
Activated by light.
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Word Map
- 1.1.1.82
- chloroplast
-
nadp-malate
- dikinase
-
3.1.3.11
-
ferredoxin-thioredoxin
- agriculture
The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria
Synonyms
nadp malate dehydrogenase, nadp-linked malate dehydrogenase, malate nadp dehydrogenase, malate dehydrogenase (nadp+), 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
dehydrogenase, malate (nicotinamide adenine dinucleotide phosphate)
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L-malate:NAD oxidoreductase
malate NADP dehydrogenase
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malic dehydrogenase (nicotinamide adenine dinucleotide phosphate)
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MDH
NADP malate dehydrogenase
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NADP+-dependent malate dehydrogenase
NADP-dependent malate dehydrogenase
NADP-linked malate dehydrogenase
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NADP-malate dehydrogenase
NADP-malic enzyme
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NADP-MDH
NADP-malate dehydrogenase
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NADP-MDH
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
(S)-malate + NADP+ = oxaloacetate + NADPH + H+
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(S)-malate + NADP+ = oxaloacetate + NADPH + H+
The enzyme is highly conserved with plant counterparts, but bearing differences at regulatory determinants with a critical role for redox control of protein activity
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY SOURCE
PATHWAYS
KEGG
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SYSTEMATIC NAME
IUBMB Comments
(S)-malate:NADP+ oxidoreductase
Activated by light.
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CAS REGISTRY NUMBER
COMMENTARY
37250-19-4
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(S)-malate + NADP+
oxaloacetate + NADPH + H+
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-
-
-
r
(S)-malate + NADP+
oxaloacetate + NADPH + H+
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at pH 8.9 the rate in the direction of NADH oxidation is about 30times that for the reverse direction
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r
oxaloacetate + NADH
(S)-malate + NAD+
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activity with NADPH is about 2.5times that with NADH
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?
oxaloacetate + NADH
(S)-malate + NAD+
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utilization of NADH to NADPH in reduction of oxaloacetate is 1:160
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?
oxaloacetate + NADPH
(S)-malate + NADP+
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under physiological conditions the enzyme functions in the direction of malate formation. Enzyme probably functions in providing the cytoplasm with reducing equivalents in the form of malate which in addition to its various roles, can be used for generation of carbon skeletons for amino acid biosynthesis
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?
oxaloacetate + NADPH
(S)-malate + NADP+
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the enzyme contributes to malate formation during the operation of the C4-dicarboxylic acid pathway of photosynthesis, it possibly also has a photosynthetic function in Calvin cycle plants
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?
oxaloacetate + NADPH
(S)-malate + NADP+
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enzyme functions in C4 pathway of photosynthesis
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?
oxaloacetate + NADPH
(S)-malate + NADP+
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enzyme may have a common role in both Calvin cycle and C4-photosynthesis
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?
oxaloacetate + NADPH
(S)-malate + NADP+
-
the enzyme contributes to malate formation during the operation of the C4-dicarboxylic acid pathway of photosynthesis, it possibly also has a photosynthetic function in Calvin cycle plants
-
?
oxaloacetate + NADPH
(S)-malate + NADP+
-
the enzyme contributes to malate formation during the operation of the C4-dicarboxylic acid pathway of photosynthesis, it possibly also has a photosynthetic function in Calvin cycle plants
-
?
oxaloacetate + NADPH
(S)-malate + NADP+
-
important enzyme of photosynthetic CO2 fixation
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?
oxaloacetate + NADPH
(S)-malate + NADP+
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key enzyme of the photosynthetic pathway of C4 plants
-
?
oxaloacetate + NADPH
(S)-malate + NADP+
-
the enzyme contributes to malate formation during the operation of the C4-dicarboxylic acid pathway of photosynthesis, it possibly also has a photosynthetic function in Calvin cycle plants
-
?
oxaloacetate + NADPH
(S)-malate + NADP+
-
enzyme may have a common role in both Calvin cycle and C4-photosynthesis
-
?
oxaloacetate + NADPH
(S)-malate + NADP+
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when no reoxidation of the light-generated NADPH can take place because of a lack of electron acceptors, full activation of the enzyme as well as reduction of thioredioxin m is observed. The fine regulation of the reductive activation of the enzyme determines the actual extent of export of reducing equivalents, in the form of malate, via the dicarboxylic acid translocator
-
?
oxaloacetate + NADPH
(S)-malate + NADP+
-
at pH 8.9 the rate in the direction of NADH oxidation is about 30times that for the reverse direction
-
r
oxaloacetate + NADPH
(S)-malate + NADP+
-
the enzyme contributes to malate formation during the operation of the C4-dicarboxylic acid pathway of photosynthesis, it possibly also has a photosynthetic function in Calvin cycle plants
-
?
oxaloacetate + NADPH
(S)-malate + NADP+
-
key enzyme of the photosynthetic pathway of C4 plants
-
?
oxaloacetate + NADPH
(S)-malate + NADP+
-
key enzyme of the photosynthetic pathway of C4 plants
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?
oxaloacetate + NADPH + H+
(S)-malate + NADP+
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r
oxaloacetate + NADPH + H+
(S)-malate + NADP+
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r
additional information
?
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the preferential use of NADPH as the cofactor is due to the presence of glycine at position 33
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?
additional information
?
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NADPH is oxidized and oxalacetate is reduced to malate by NADP-MDH
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?
additional information
?
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NADPH is oxidized and oxalacetate is reduced to malate by NADP-MDH
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?
additional information
?
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the preferential use of NADPH as the cofactor is due to the presence of glycine at position 33
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?
additional information
?
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the preferential use of NADPH as the cofactor is due to the presence of glycine at position 33
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?
additional information
?
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the dual specificity for the cofactor results from alanine at position 53 in Methanobacterium jannaschii
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?
additional information
?
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the preferential use of NADPH as the cofactor is due to the presence of glycine at position 33
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?
additional information
?
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the preferential use of NADPH as the cofactor is due to the presence of glycine at position 33
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-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(S)-malate + NADP+
oxaloacetate + NADPH + H+
-
-
-
-
r
oxaloacetate + NADPH
(S)-malate + NADP+
-
under physiological conditions the enzyme functions in the direction of malate formation. Enzyme probably functions in providing the cytoplasm with reducing equivalents in the form of malate which in addition to its various roles, can be used for generation of carbon skeletons for amino acid biosynthesis
-
?
oxaloacetate + NADPH
(S)-malate + NADP+
-
the enzyme contributes to malate formation during the operation of the C4-dicarboxylic acid pathway of photosynthesis, it possibly also has a photosynthetic function in Calvin cycle plants
-
?
oxaloacetate + NADPH
(S)-malate + NADP+
-
enzyme functions in C4 pathway of photosynthesis
-
?
oxaloacetate + NADPH
(S)-malate + NADP+
-
enzyme may have a common role in both Calvin cycle and C4-photosynthesis
-
?
oxaloacetate + NADPH
(S)-malate + NADP+
-
the enzyme contributes to malate formation during the operation of the C4-dicarboxylic acid pathway of photosynthesis, it possibly also has a photosynthetic function in Calvin cycle plants
-
?
oxaloacetate + NADPH
(S)-malate + NADP+
-
the enzyme contributes to malate formation during the operation of the C4-dicarboxylic acid pathway of photosynthesis, it possibly also has a photosynthetic function in Calvin cycle plants
-
?
oxaloacetate + NADPH
(S)-malate + NADP+
-
important enzyme of photosynthetic CO2 fixation
-
?
oxaloacetate + NADPH
(S)-malate + NADP+
-
key enzyme of the photosynthetic pathway of C4 plants
-
?
oxaloacetate + NADPH
(S)-malate + NADP+
-
the enzyme contributes to malate formation during the operation of the C4-dicarboxylic acid pathway of photosynthesis, it possibly also has a photosynthetic function in Calvin cycle plants
-
?
oxaloacetate + NADPH
(S)-malate + NADP+
-
enzyme may have a common role in both Calvin cycle and C4-photosynthesis
-
?
oxaloacetate + NADPH
(S)-malate + NADP+
-
when no reoxidation of the light-generated NADPH can take place because of a lack of electron acceptors, full activation of the enzyme as well as reduction of thioredioxin m is observed. The fine regulation of the reductive activation of the enzyme determines the actual extent of export of reducing equivalents, in the form of malate, via the dicarboxylic acid translocator
-
?
oxaloacetate + NADPH
(S)-malate + NADP+
-
the enzyme contributes to malate formation during the operation of the C4-dicarboxylic acid pathway of photosynthesis, it possibly also has a photosynthetic function in Calvin cycle plants
-
?