EC Number   |
Expression |
Reference |
|---|
    1.14.17.1 | down |
A53T Tg mice that express human A53T variant alpha-synuclein under the direction of the mouse prion protein promoter show decreased DBH expression. A53T Tg mice exhibit anxiety-like behaviors and abnormal adaptive responses following the repeated immobilization stress |
744851 |
| 1.14.17.1 | down |
alpha-SYN enters the nucleus and binds directly to the DBH promoter region. alpha-Syn atteniúates the forskolin-induced DBH upregulation in SK-N-BE(2) cells |
744851 |
| 1.14.17.1 | up |
both in adrenal medulla and stellate ganglia, single immobilization significantly increases DBH mRNA and protein levels both in wild-type and corticotropin-releasing hormone knockout mice |
701704 |
| 1.14.17.1 | up |
Cu-negative samples have significantly higher DBM activity than Cu-positive samples in both adrenal glands (2.4fold) and medulla oblongata/pons (0.9fold), but not vas deferens. No correlation between higher DBM mRNA and lower noradrenaline in Cu-negative tissues |
702945 |
| 1.14.17.1 | up |
DBM protein abundance in adrenal glands is higher in the Cu-negative samples compared with Cu-positive samples |
702945 |
| 1.14.17.1 | down |
Egr1 reduces DBH promoter activity, reduction occurrs as early as 4 h and reaches maximal inhibition 16-40 h after transfection. Egr1 also reduces the expression of endogenous DBH mRNA and the induction of DBH promoter activity by cAMP. The first 247, but not 200, nucleotides of DBH promoter are sufficient for suppression |
702956 |
| 1.14.17.1 | down |
enzyme downregulation by LvDBH-dsRNA |
744950 |
| 1.14.17.1 | up |
enzyme expression is highest in 5-weeks-old rats |
727633 |
| 1.14.17.1 | up |
forced expression of Trim11 with Phox2b specifically increases mRNA levels of dopamine beta-hydroxylase gene in primary avian neural crest stem cell culture compared to cultures where only Phox2b is forced expressed |
702012 |
| 1.14.17.1 | up |
forskolin, dexamethasone, ionomycin, and 17-beta-estradiol all induce a significant increase in DBH promoter activity, the most significant 15.8fold upregulation of DBH transcription is observed in forskolin-treated cells The forskolin-induced DBH upregulation in SK-N-BE(2) cells is attenuated by alpha-Syn. CRE-mediated transcriptional regulation of tyrosine hydroxylase and enzyme DBH plays a crucial role in stress response |
744851 |
