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Results 1 - 10 of 13 > >>
EC Number Expression Commentary Reference
Show all pathways known for 1.14.17.1Display the word mapDisplay the reaction diagram Show all sequences 1.14.17.1up both in adrenal medulla and stellate ganglia, single immobilization significantly increases DBH mRNA and protein levels both in wild-type and corticotropin-releasing hormone knockout mice 701704
Show all pathways known for 1.14.17.1Display the word mapDisplay the reaction diagram Show all sequences 1.14.17.1up forced expression of Trim11 with Phox2b specifically increases mRNA levels of dopamine beta-hydroxylase gene in primary avian neural crest stem cell culture compared to cultures where only Phox2b is forced expressed 702012
Show all pathways known for 1.14.17.1Display the word mapDisplay the reaction diagram Show all sequences 1.14.17.1up Cu-negative samples have significantly higher DBM activity than Cu-positive samples in both adrenal glands (2.4fold) and medulla oblongata/pons (0.9fold), but not vas deferens. No correlation between higher DBM mRNA and lower noradrenaline in Cu-negative tissues 702945
Show all pathways known for 1.14.17.1Display the word mapDisplay the reaction diagram Show all sequences 1.14.17.1up DBM protein abundance in adrenal glands is higher in the Cu-negative samples compared with Cu-positive samples 702945
Show all pathways known for 1.14.17.1Display the word mapDisplay the reaction diagram Show all sequences 1.14.17.1down Egr1 reduces DBH promoter activity, reduction occurrs as early as 4 h and reaches maximal inhibition 16-40 h after transfection. Egr1 also reduces the expression of endogenous DBH mRNA and the induction of DBH promoter activity by cAMP. The first 247, but not 200, nucleotides of DBH promoter are sufficient for suppression 702956
Show all pathways known for 1.14.17.1Display the word mapDisplay the reaction diagram Show all sequences 1.14.17.1down transfection of shRNAs specific to Phox2a or Phox2b genes significantly reduces mRNA and protein levels of DBH after shutdown of endogenous Phox2, which is accompanied by a decreased [(3)H]norepinephrine uptake. Reduced DBH expression caused by the shRNA specific to Phox2a can be reversed by transfection with Phox2b cDNA and vice versa. Cotransfection with both shRNAs specific to Phox2a and Phox2b genes does not further reduce mRNA and protein levels of DBH 705254
Show all pathways known for 1.14.17.1Display the word mapDisplay the reaction diagram Show all sequences 1.14.17.1up transfection of 0.1 to 5 microg of cDNAs of Phox2a or Phox2b significantly increases mRNA and protein levels of DBH (up to 47%) in a concentration-dependent manner. Simultanoeus transfection with both Phox2a and Phox2b does not further increase mRNA and protein levels of DBH 705254
Show all pathways known for 1.14.17.1Display the word mapDisplay the reaction diagram Show all sequences 1.14.17.1up enzyme expression is highest in 5-weeks-old rats 727633
Show all pathways known for 1.14.17.1Display the word mapDisplay the reaction diagram Show all sequences 1.14.17.1down A53T Tg mice that express human A53T variant alpha-synuclein under the direction of the mouse prion protein promoter show decreased DBH expression. A53T Tg mice exhibit anxiety-like behaviors and abnormal adaptive responses following the repeated immobilization stress 744851
Show all pathways known for 1.14.17.1Display the word mapDisplay the reaction diagram Show all sequences 1.14.17.1down alpha-SYN enters the nucleus and binds directly to the DBH promoter region. alpha-Syn atteniúates the forskolin-induced DBH upregulation in SK-N-BE(2) cells 744851
Results 1 - 10 of 13 > >>