EC Number   |
Posttranslational Modification |
Reference |
|---|
   3.4.24.B11 | proteolytic modification |
cleavage at the consensus subtilisin site RKKR resulting in 2 different processed forms of MW 85 kDa and 67 kDa |
651941 |
| 3.4.24.B11 | proteolytic modification |
cleavage of prodomain by furin at furin-cleavage site RKKR |
649597 |
| 3.4.24.B11 | proteolytic modification |
cleavage of the proform by furin at the furin cleavage site |
651525 |
| 3.4.24.B11 | proteolytic modification |
enzyme is synthesized as an inactive proform, proteolytical processing of a conserved cysteine residue in its prodomain |
652621 |
| 3.4.24.B11 | proteolytic modification |
processing by furin endopeptidase in vivo |
651928 |
| 3.4.24.B11 | proteolytic modification |
recombinant enzyme is also processed in insect cells |
651153 |
| 3.4.24.B11 | proteolytic modification |
secreted pro-METH-1 is processed in 2 consecutive steps to release a p87 and a p65 active form, cleavage by furin results in only the p87 fragment, the p87 form lacks the N-terminal prodomain, and p65 results from an additional processing event in the C-terminus requiring p87 which can be catalyzed by matrix metalloproteases 2,8, and 15 |
652049 |
