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Literature summary for 3.4.24.B11 extracted from

  • Tang, B.L.
    ADAMTS: a novel family of extracellular matrix proteases (2001), Int. J. Biochem. Cell Biol., 33, 33-44.
    View publication on PubMed
Search for more literature for 3.4.24.B11

Activating Compound

Activating Compound Comment Organism Structure
cytokine stimulation of gene expression in colon carcinoma cell line Mus musculus
interleukin-1 stimulation of gene expression in colon carcinoma cell line Mus musculus
additional information complex formation with alpha2-macroglobulin Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information knock out mutant mice exhibit significant growth retardation, impaired female fertility and adipose tissue malformation, as well as kidney structure changes Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular matrix, soluble Homo sapiens
-
-
extracellular the mature processed enzyme form is soluble, the unprocessed enzyme proform is associated with the extracellular matrix via the first TSP-1 repeat that can bind to heparin Mus musculus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ enzyme contains a Zn2+-binding peptidase consensus sequence HEXXH involved in catalysis Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme is genetically regulated by progesteron in the ovulation process ?
-
 ?
proteins + H2O Mus musculus
-
 peptides
-
 ?
proteins + H2O Homo sapiens
-
 peptides
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UHI8
-
-
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification cleavage of the proform by furin at the furin cleavage site Mus musculus

Reaction

Reaction Comment Organism Reaction ID
proteolytic degradation of proteins enzyme has multiple and non-redundant functions in organogenesis, enzyme inhibits endothelial cell proliferation Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
colonic cancer cell selective expression and secretion Mus musculus
-
heart low expression level Mus musculus
-
kidney low expression level Mus musculus
-
kidney high level gene expression Homo sapiens
-
additional information intravenous administration of lipopolysaccharides resulted in inflammation which induced the enzyme expression exclusively in heart and kidney Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme is genetically regulated by progesteron in the ovulation process Homo sapiens ?
-
 ?
proteins + H2O
-
 Mus musculus peptides
-
 ?
proteins + H2O
-
 Homo sapiens peptides
-
 ?
proteins + H2O enzyme suppresses FGF2-induced vascularization in a cornea pocket assay and inhibited VEGF-induced angiogenesis in a chorioallantoic membrane assay Homo sapiens peptides
-
 ?

Subunits

Subunits Comment Organism
More enzyme is composed of a ADAM-like protease domain, a disintegrin-like, a thrombospondin type 1 repeat and a cysteine-rich domain, but no transmembrane domain Mus musculus
More enzyme is composed of a ADAM-like protease domain, a disintegrin-like, a thrombospondin type 1 repeat and a cysteine-rich domain, but no transmembrane domain Homo sapiens

Synonyms

Synonyms Comment Organism
a disintegrin and metalloproteinase with thrombospondin motifs 1
-
 Mus musculus
a disintegrin and metalloproteinase with thrombospondin motifs 1
-
 Homo sapiens
ADAMTS1
-
 Mus musculus
ADAMTS1
-
 Homo sapiens
M12.222 Merops-ID Mus musculus
M12.222 Merops-ID Homo sapiens
METH-1
-
 Homo sapiens