EC Number   |
Application |
Reference |
|---|
    2.7.1.145 | agriculture |
multifunctional deoxynucleoside kinase of insect cells is a target for development of new highly selective insecticidial drugs |
636843 |
| 2.7.1.145 | medicine |
deoxynucleoside kinase gene is introduced into HeLa cells with cationic lipids, to allow its transient expression. Cytotoxicities of 1-beta-D-arabinofuranosylcytosine, 5-fluorodeoxyuridine, and 1-(2-deoxy-2-methylene-beta-D-erythro-pentofuranosyl)cytosine are increased by the deoxynucleoside kinase gene. The combination of the transient expression of the Drosophila deoxynucleoside kinase gene and these nucleoside analogs is a candidate for suicide gene therapy |
676247 |
| 2.7.1.145 | medicine |
enzyme with increased specificity towards certain analogues can be used as a suicide gene in combined gene/chemotherapy treatment of cancer |
661453, 662967 |
| 2.7.1.145 | medicine |
lentivirusx1emediated Drosophila melanogaster deoxyribonucleoside kinase combined with (E)-5-(2-bromovinyl)-2'-deoxyuridine or 1-beta-D-arabinofuranosylthymine therapy may be effective in treating keloid fibroblasts |
761914 |
| 2.7.1.145 | medicine |
mitochondrial targeting of Dm-dNK facilitates nucleoside and nucleoside analog phosphorylation and could be used as a strategy to enhance the efficacy of nucleoside analog phosphorylation and concomitantly their cytostatic potential |
676100 |
| 2.7.1.145 | medicine |
mitochondrial targeting of multisubstrate nucleoside kinase facilitates nucleoside and nucleoside analog phosphorylation and could be used as a strategy to enhance the efficacy of nucleoside analog phosphorylation and concomitantly their cytostatic potential |
676100 |
| 2.7.1.145 | medicine |
possible use of this enzyme as a suicide gene in vitro and in vivo |
739211 |
| 2.7.1.145 | medicine |
suicide gene dmdnk in several cancer cell lines, overview. In vivo testing in a xenograft model for breast cancer, both wild-type DmdNK and mutants of DmdNK are combined with gemcitabine (dFdC, 2',2'-difluoro-deoxycytidine) as the NA prodrug and a positive effect of decreasing tumor volume and increased survival time |
738781 |
| 2.7.1.145 | medicine |
the enzyme activates a number of medically important nucleoside analogues |
662932 |
| 2.7.1.145 | medicine |
the enzyme can be used as a suicide gene in combined gene/chemotherapy treatment of cancer |
660852, 662990 |
