EC Number |
Metals/Ions |
Reference |
---|
2.7.11.11 | Ca2+ |
extracellular Ca2+ is required for enzyme activity in sperm |
661558 |
2.7.11.11 | Cd2+ |
can partially substitue Mg2+ |
490935 |
2.7.11.11 | Co2+ |
can partially substitue Mg2+ |
490935 |
2.7.11.11 | Mg2+ |
- |
490931, 660567, 660682, 660791, 660803, 661013, 661073, 661135, 661266, 661314, 661480, 661558, 661746, 661759, 662154, 662180, 662206, 662212, 662279, 662302, 662321, 662347, 662378, 662380, 662386, 662393, 662452, 662491, 662614, 662674, 662675, 662681, 662708, 662709, 662851, 662873, 663212, 663236, 663295, 663349, 663394, 671678, 672227, 672647, 673601, 673866, 674804, 674837, 675021, 675598, 675671, 676192, 677184 |
2.7.11.11 | Mg2+ |
absolutely required, as MgATP2-, best at 0.5 mM Mg2+, inhibitory at higher Mg2+ concentrations, cannot be substituted by Mn2+ |
661884 |
2.7.11.11 | Mg2+ |
activates |
737679 |
2.7.11.11 | Mg2+ |
activates the enzyme, binds to beta- and gamma-phosphate of ATP and to Asp184 |
490800 |
2.7.11.11 | Mg2+ |
as MgATP2-, binding site structure |
662608 |
2.7.11.11 | Mg2+ |
dependent on, chelates the beta- and gamma-phosphate of ATP, Mg2+ is the physiologic metal ion, other divalent cations are able to support nucleotide binding, but only Mn2+, Co2+, and Cd2+ can substitute Mg2+ in supporting the catalytic activity |
490935 |
2.7.11.11 | Mg2+ |
highest activity in the presence of Mg2+ |
737693 |