EC Number   |
Inhibitors |
Structure  |
|---|
    4.3.2.1 | more |
the antibody of the liver enzyme is an effective inhibitor of brain enzyme |
 |
| 4.3.2.1 | more |
mRNA expression and activity of liver argininosuccinate lyase decrease with age |
|
| 4.3.2.1 | more |
acetylation at Lys288 or Lys69 decreases activity of ASL |
|
| 4.3.2.1 | D-glucose |
12.5 mM glucose decreases activity of ASL by 20%, 25 mM glucose by 50% |
  |
| 4.3.2.1 | succinate |
dead-end inhibitor |
|
| 4.3.2.1 | succinate |
noncompetitive vs. fumarate and arginine |
|
| 4.3.2.1 | Urea |
competitive |
|
| 4.3.2.1 | fumarate |
noncompetitive versus argininosuccinate |
|
| 4.3.2.1 | fumarate |
a potential feedback mechanism is proposed, wherein the Cys441 is covalently modified to S-(2-succinyl) cysteine by one of the products, fumarate |
|
| 4.3.2.1 | Arg |
noncompetitive versus argininosuccinate |
|
