EC Number |
Inhibitors |
Structure |
---|
4.3.2.1 | acetylenedicarboxylate |
- |
|
4.3.2.1 | diethyl dicarbonate |
- |
|
4.3.2.1 | N3-(L-1-carboxy-2-nitroethyl)-L-arginine |
- |
|
4.3.2.1 | argininosuccinate |
0.3 mM inhibits the reaction by 97% |
|
4.3.2.1 | D-glucose |
12.5 mM glucose decreases activity of ASL by 20%, 25 mM glucose by 50% |
|
4.3.2.1 | fumarate |
a potential feedback mechanism is proposed, wherein the Cys441 is covalently modified to S-(2-succinyl) cysteine by one of the products, fumarate |
|
4.3.2.1 | more |
acetylation at Lys288 or Lys69 decreases activity of ASL |
|
4.3.2.1 | bromomesaconic acid |
argininosuccinate completely protects, Lys51 has an essential role in binding of argininosuccinate and consequently is essential in catalysis; inactivation follows pseudo-first-order kinetics |
|
4.3.2.1 | 1-ethyl-3-(3-diethylaminopropyl)carbodiimide |
at pH 6 |
|
4.3.2.1 | Urea |
competitive |
|