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EC Number
Activating Compound
Commentary
Reference
3.4.19.3
1,10-phenanthroline
weak activation
95283
3.4.19.3
cyclosporin
increases particulate and soluble PAP activity in the renal cortex. Particulate PAP activity returns to levels similar to controls after 15 days of cyclosporin withdrawal, soluble PAP does not regress. Soluble and particulate aminopeptidases in resident and elicited macrophages are unaffected by cyclosporin
680172
3.4.19.3
DFP
weak activation
95283
3.4.19.3
dithiothreitol
-
678405
,
682806
3.4.19.3
dithiothreitol
absolute requirement for maintenance of activity
95301
3.4.19.3
dithiothreitol
at least 10 mM required for full activity
681817
3.4.19.3
dithiothreitol
presence of disulfide-reducing agent such as dithiothreitol required
95296
3.4.19.3
dithiothreitol
rapid increase in activity from 2 to 6 mM, above this concentration plateau effect
681896
3.4.19.3
dithiothreitol
strongly stimulates activity of wild-type enzyme and mutant enzyme C188S and shifts the pH-optimum to higher temperatures by about 10°C
651099
3.4.19.3
DTT
enhances activity
653129
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