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Information on EC 6.3.4.18 - 5-(carboxyamino)imidazole ribonucleotide synthase

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IUBMB Comments
In Escherichia coli, this enzyme, along with EC 5.4.99.18, 5-(carboxyamino)imidazole ribonucleotide mutase, is required to carry out the single reaction catalysed by EC 4.1.1.21, phosphoribosylaminoimidazole carboxylase, in vertebrates. Belongs to the ATP grasp protein superfamily . Carboxyphosphate is the putative acyl phosphate intermediate. Involved in the late stages of purine biosynthesis.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
More, N5-CAIR synthetase, N5-carboxyaminoimidazole ribonucleotide synthetase, N5-carboxylaminoimidazole ribonucleotide synthetase, N5CAIR synthetase, PurK, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole
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