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Information on EC 4.3.3.5 - 4'-demethylrebeccamycin synthase

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EC Tree
     4 Lyases
         4.3 Carbon-nitrogen lyases
             4.3.3 Amine-lyases
                4.3.3.5 4'-demethylrebeccamycin synthase
IUBMB Comments
This enzyme catalyses a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is a glycosylase, and acts in the reverse direction to that shown. It has a wide substrate range, and was shown to glycosylate several substrates, including the staurosporine aglycone, EJG-III-108A, J-104303, 6-N-methyl-arcyriaflavin C and indolo-[2,3-a]-carbazole [1,2].
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The expected taxonomic range for this enzyme is: Lechevalieria aerocolonigenes
Synonyms
ngt, RebG, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4'-O-demethylrebeccamycin + H2O = dichloro-arcyriaflavin A + beta-D-glucose
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