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Information on EC 4.2.1.80 - 2-oxopent-4-enoate hydratase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.80 2-oxopent-4-enoate hydratase
IUBMB Comments
The enzyme is involved in the catechol meta-cleavage pathway, a major mechanism for degradation of aromatic compounds. Also acts, more slowly, on cis-2-oxohex-4-enoate, but not on the trans-isomer. The enzyme was named when it was thought that the substrate is 2-oxopent-4-enoate. However, it was later found that the actual substrate is its tautomer (2Z)-2-hydroxypenta-2,4-dienoate. In some organisms the enzyme forms a complex with EC 4.1.1.77, 2-oxo-3-hexenedioate decarboxylase (previously named 4-oxalocrotonate decarboxylase).
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
2-hydroxypent-2,4-dienoate hydratase, 2-hydroxypenta-2,4-dienoate hydratase, 2-hydroxypentadienoic acid hydratase, 2-keto-4-pentenoate hydratase, 2-keto-4-pentenoate(vinylpyruvate)hydratase, 2-keto-4-pentenoic acid hydratase, BphH, HPD hydratase, MhpD, OEH 2-keto-4-pentenoate hydratase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(S)-4-hydroxy-2-oxopentanoate = (2Z)-2-hydroxypenta-2,4-dienoate + H2O
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