Information on EC - Phthalyl amidase

for references in articles please use BRENDA:EC3.5.1.79
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EC Tree
     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
       Phthalyl amidase
IUBMB Comments
In the entry, "phthalyl" is used to mean "2-carboxybenzoyl". The enzyme from Xanthobacter agilis hydrolyses phthalylated amino acids, peptides, beta-lactams, aromatic and aliphatic amines. The substituent on nitrogen may be an alkyl group, but may also be complex, giving an amino acid or peptide derivative. Substitutions on the phthalyl ring include 6-F, 6-NH2, 3-OH, and a nitrogen in the aromatic ring ortho to the carboxy group attached to the amine. No cofactors are required
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The expected taxonomic range for this enzyme is: Bacteria, Archaea
phthalyl amidase, more
A phthalylamide + H2O = phthalic acid + a substituted amine
show the reaction diagram
Xanthobacter agilis
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