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(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + geranylgeranyl diphosphate
(Z)-ethynyldimethylallyl diphosphate + isopentenyl diphosphate
(Z)-ethynylfarnesyl diphosphate + diphosphate
-
-
sole product with wild-type, yield is 21.9% Z-ethynylfarnesyl diphosphate, compared with 100% for the reaction of dimethylallyl diphosphate with isopentenyl diphosphate
-
?
2 dimethylallyl diphosphate
diphosphate + chrysanthemyl diphosphate
reaction of EC 2.5.1.67, chrysanthemyl diphosphate synthase is an inefficient promiscuous enzyme, which synthesizes the irregular monoterpenes chrysanthemyl diphosphate (CPP), lavandulyl diphosphate (LPP), and trace quantities of maconelliyl diphosphate (MPP) from two molecules of DMAPP, and couples IPP to DMAPP to give GPP
-
-
?
2 dimethylallyl diphosphate
diphosphate + lavandulyl diphosphate
reaction of EC 2.5.1.69, chrysanthemyl diphosphate synthase is an inefficient promiscuous enzyme, which synthesizes the irregular monoterpenes chrysanthemyl diphosphate (CPP), lavandulyl diphosphate (LPP), and trace quantities of maconelliyl diphosphate (MPP) from two molecules of DMAPP, and couples IPP to DMAPP to give GPP
-
-
?
cyclohexylideneethyl diphosphate + 2-cyclohexenylethyl diphosphate
(cyclohexylideneethyl)-cyclohexylideneethyl diphosphate
-
-
relative yield 0.8%
-
?
cyclohexylideneethyl diphosphate + isopentenyl diphosphate
10-cyclohexyliden-3,7-dimethyldeca-2,6-dien-1-ol + ?
dimethylallyl diphosphate + (R)-benzodiazepinedione
aszonalenin + diphosphate
-
-
-
-
?
dimethylallyl diphosphate + 2 isopentenyl diphosphate
2 diphosphate + farnesyl diphosphate
-
in the presence of Mg2+
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
(E)-geranyl diphosphate + diphosphate
dimethylallyl diphosphate + isopentenyl diphosphate
(E,E)-farnesyl diphosphate + geranyl diphosphate + diphosphate
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
dimethylallyl diphosphate + isopentenyl diphosphate
geranyl diphosphate + diphosphate
diphosphate + farnesyl diphosphate
?
diphosphate + geranyl diphosphate
dimethylallyl diphosphate + isopentenyl diphosphate
geranyl diphosphate + (3S)-3-(1H-indol-3-ylmethyl)-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione
(3S)-3-([6-[(2Z)-2-ethylidene-6-methylhept-5-en-1-yl]-1H-indol-3-yl]methyl)-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione + (3S)-3-([7-[(2Z)-7-methylocta-2,6-dien-1-yl]-1H-indol-3-yl]methyl)-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione + diphosphate
-
-
31% + 60% yield
-
?
geranyl diphosphate + (3S,6R)-3-(4-hydroxybenzyl)-6-(1H-indol-3-ylmethyl)piperazine-2,5-dione
(3R,6S)-3-([6-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-1H-indol-3-yl]methyl)-6-[(4-hydroxyphenyl)methyl]piperazine-2,5-dione + (3R,6S)-3-([7-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-1H-indol-3-yl]methyl)-6-[(4-hydroxyphenyl)methyl]piperazine-2,5-dione + diphosphate
-
-
32% + 13% yield
-
?
geranyl diphosphate + (3S,6S)-3,6-bis(1H-indol-3-ylmethyl)piperazine-2,5-dione
(3S,6S)-3-([6-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1H-indol-3-yl]methyl)-6-[(1H-indol-3-yl)methyl]piperazine-2,5-dione + (3S,6S)-3-([7-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-1H-indol-3-yl]methyl)-6-[(1H-indol-3-yl)methyl]piperazine-2,5-dione + diphosphate
-
-
15% + 35% yield
-
?
geranyl diphosphate + (3S,6S)-3-(1H-indol-3-ylmethyl)-6-(2-methylpropyl)piperazine-2,5-dione
(3S,6S)-3-([6-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1H-indol-3-yl]methyl)-6-(2-methylpropyl)piperazine-2,5-dione + (3S,6S)-3-([7-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1H-indol-3-yl]methyl)-6-(2-methylpropyl)piperazine-2,5-dione + diphosphate
-
-
15% + 57% yield
-
?
geranyl diphosphate + (3S,6S)-3-(4-hydroxybenzyl)-6-(1H-indol-3-ylmethyl)piperazine-2,5-dione
(3R,6R)-3-([6-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-1H-indol-3-yl]methyl)-6-[(4-hydroxyphenyl)methyl]piperazine-2,5-dione + (3S,6S)-3-([7-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-1H-indol-3-yl]methyl)-6-[(4-hydroxyphenyl)methyl]piperazine-2,5-dione + diphosphate
-
-
9% + 24% yield
-
?
geranyl diphosphate + (R)-benzodiazepinedione
(3R)-3-([6-[(2Z)-2-ethylidene-6-methylhept-5-en-1-yl]-1H-indol-3-yl]methyl)-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione + diphosphate
-
-
88% yield
-
?
geranyl diphosphate + 2-cyclohexenylethyl diphosphate
(S)-geranylcyclohexylideneethyl diphosphate + diphosphate
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2E,6E)-farnesyl diphosphate
methoxymethoxydimethylallyl diphosphate + isopentenyl diphosphate
methoxymethoxygeranyl diphosphate + diphosphate
propoxygeranyl diphosphate + isopentenyl diphosphate
propoxyfarnesyl diphosphate + diphosphate
vinyldimethylallyl diphosphate + isopentenyl diphosphate
vinylgeranyl diphosphate + vinylfarnesyl diphosphate + diphosphate
-
-
14.3% vinylgeranyl diphosphate plus 23.3% vinylfarnesyl diphosphate, compared with 100% for the reaction of dimethylallyl diphosphate with isopentenyl diphosphate
-
?
additional information
?
-
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + geranylgeranyl diphosphate
reaction of EC 2.5.1.29, the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate
-
-
?
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + geranylgeranyl diphosphate
reaction of EC 2.5.1.29, the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate. Under environmental stresses, Haematococcus pluvialis accumulates large amounts of carotenoids. Scale of carotenoid biosynthesis depends on availability of geranylgeranyl pyrophosphate precursor, which is supplied by GGPP synthase through sequential 1'-4 condensation of three isopentenyl pyrophosphates into dimethylallyl pyrophosphate
-
-
?
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + geranylgeranyl diphosphate
reaction of EC 2.5.1.29, the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate
-
-
?
cyclohexylideneethyl diphosphate + isopentenyl diphosphate
10-cyclohexyliden-3,7-dimethyldeca-2,6-dien-1-ol + ?
-
-
double condensation product, relative yield 23.1%
-
?
cyclohexylideneethyl diphosphate + isopentenyl diphosphate
10-cyclohexyliden-3,7-dimethyldeca-2,6-dien-1-ol + ?
-
-
double condensation product, relative yield 3.0%
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
(E)-geranyl diphosphate + diphosphate
-
-
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
(E)-geranyl diphosphate + diphosphate
-
-
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
(E,E)-farnesyl diphosphate + geranyl diphosphate + diphosphate
-
ratio geranyl diphosphate/farnesyl diphosphate is about 2:1
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
(E,E)-farnesyl diphosphate + geranyl diphosphate + diphosphate
-
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
in the presence of Co2+
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
chrysanthemyl diphosphate synthase is an inefficient promiscuous enzyme, which synthesizes the irregular monoterpenes chrysanthemyl diphosphate (CPP), lavandulyl diphosphate (LPP), and trace quantities of maconelliyl diphosphate (MPP) from two molecules of DMAPP, and couples IPP to DMAPP to give GPP
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
the enzyme catalyzes the condensation of two molecules of isopentenyl diphosphate with dimethylallyl diphosphate to generate the C15 product (2E,6E)-farnesyl diphosphate
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
-
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
-
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
the enzyme catalyzes the condensation of two molecules of isopentenyl diphosphate with dimethylallyl diphosphate to generate the C15 product (2E,6E)-farnesyl diphosphate
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
highest catalytic efficiency
-
-
r
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
highest catalytic efficiency
-
-
r
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
-
relative yield 100%
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate. Under environmental stresses, Haematococcus pluvialis accumulates large amounts of carotenoids. Scale of carotenoid biosynthesis depends on availability of geranylgeranyl pyrophosphate precursor, which is supplied by GGPP synthase through sequential 1'-4 condensation of three isopentenyl pyrophosphates into dimethylallyl pyrophosphate
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
reaction of EC 2.5.1.1, the enzyme catalyzes the condensation of dimethylallyl pyrophosphate and isopentenyl pyrophosphate, forming geranyl pyrophosphate and then farnesyl pyrophosphate
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
the enzyme catalyses the sequential condensation of dimethylallyl diphosphate with isopentenyl diphosphate (IPP) and the resulting geranyl diphosphate (GPP) with another unit of IPP, eventually producing the 15-carbon isoprenoid farnesyl diphosphate
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
the enzyme catalyzes the condensation of dimethylallyl pyrophosphate and isopentenyl pyrophosphate, forming geranyl pyrophosphate and then farnesyl pyrophosphate
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
bifunctional enzyme: geranyldiphosphate synthase (EC 2.5.1.1)/myrcene synthase (EC 4.2.3.15). When the recombinant enzyme is incubated with dimethylallyl diphosphate and isopentenyl diphosphate as cosubstrates, the level of geranyl diphosphate formed is approximately tenfold higher than the level of myrcene formed. The data suggest that geranyl diphosphate is a free intermediate in myrcene production
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
-
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
-
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
the enzyme is involved in the biosynthesis of the monoterpenoid precursors needed for formation of the defensive compound chrysomelidial. Geranyl diphosphate is needed for the de novo synthesis of the cyclopentanoid monoterpene iridoids, defensive compounds that are produced during the entire larval stage of Phaedon cochleariae
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
the enzyme is bifunctional and produces (2E,6E)-farnesyl diphosphate or geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate depending on the divalent metal cofactor present. The enzyme is far more active with Co2+ as an additive than with any other tested metal ion. In the presence of Co2+ or Mn2+, with dimethylallyl diphosphate as a cosubstrate, it produces about 96% geranyl diphosphate and only 4% farnesyl diphosphate. In contrast, with Mg2+ as an additive, the enzyme produces 18% geranyl diphosphate and farnesyl diphosphate
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
geranylgeranyl diphosphate activity of enzyme leads to additional production of geranylgeranyl diphosphate. The ratio of geranyl diphosphate to geranylgeranyl diphosphate produced averages approximately 9:1. No synthesis of farnesyl diphosphate
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
the enzyme catalyzes the sequential condensation of two molecules of isopentenyl diphosphate (IPP) with dimethylallyl diphosphate (DMAPP), producing geranyl diphosphate (GPP) and farnesyl diphosphate
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
-
relative yield 100%
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
geranyl diphosphate + diphosphate
-
-
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
geranyl diphosphate + diphosphate
-
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
geranyl diphosphate + diphosphate
-
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
geranyl diphosphate + diphosphate
-
-
isoform IDS1 shows 90% yield, isoform IDS2 shows 100% yield
-
?
diphosphate + farnesyl diphosphate
?
-
-
-
-
r
diphosphate + farnesyl diphosphate
?
-
-
-
-
r
diphosphate + geranyl diphosphate
dimethylallyl diphosphate + isopentenyl diphosphate
-
-
-
-
r
diphosphate + geranyl diphosphate
dimethylallyl diphosphate + isopentenyl diphosphate
-
-
-
-
r
geranyl diphosphate + 2-cyclohexenylethyl diphosphate
(S)-geranylcyclohexylideneethyl diphosphate + diphosphate
-
-
relative yield 13.6%
-
?
geranyl diphosphate + 2-cyclohexenylethyl diphosphate
(S)-geranylcyclohexylideneethyl diphosphate + diphosphate
-
-
relative yield 42.2%
-
?
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2E,6E)-farnesyl diphosphate
reaction of EC 2.5.1.10, the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate
-
-
?
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2E,6E)-farnesyl diphosphate
reaction of EC 2.5.1.10, the enzyme catalyzes the condensation of two molecules of isopentenyl diphosphate with dimethylallyl diphosphate to generate the C15 product (2E,6E)-farnesyl diphosphate
-
-
?
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2E,6E)-farnesyl diphosphate
reaction of EC 2.5.1.10, the enzyme catalyzes the condensation of two molecules of isopentenyl diphosphate with dimethylallyl diphosphate to generate the C15 product (2E,6E)-farnesyl diphosphate
-
-
?
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2E,6E)-farnesyl diphosphate
reaction of EC 2.5.1.10, the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate. Under environmental stresses, Haematococcus pluvialis accumulates large amounts of carotenoids. Scale of carotenoid biosynthesis depends on availability of geranylgeranyl pyrophosphate precursor, which is supplied by GGPP synthase through sequential 1'-4 condensation of three isopentenyl pyrophosphates into dimethylallyl pyrophosphate
-
-
?
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2E,6E)-farnesyl diphosphate
reaction of EC 2.5.1.10, the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate
-
-
?
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2E,6E)-farnesyl diphosphate
reaction of EC 2.5.1.10, the enzyme catalyzes the condensation of dimethylallyl pyrophosphate and isopentenyl pyrophosphate, forming geranyl pyrophosphate and then farnesyl pyrophosphate
-
-
?
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2E,6E)-farnesyl diphosphate
reaction of EC 2.5.1.10. The enzyme catalyses the sequential condensation of dimethylallyl diphosphate with isopentenyl diphosphate (IPP) and the resulting geranyl diphosphate (GPP) with another unit of IPP, eventually producing the 15-carbon isoprenoid farnesyl diphosphate
-
-
?
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2E,6E)-farnesyl diphosphate
-
reaction of EC 2.5.1.10. The enzyme catalyzes the sequential condensation of two molecules of isopentenyl diphosphate (IPP) with dimethylallyl diphosphate (DMAPP), producing geranyl diphosphate (GPP) and farnesyl diphosphate
-
-
?
methoxymethoxydimethylallyl diphosphate + isopentenyl diphosphate
methoxymethoxygeranyl diphosphate + diphosphate
-
-
yield is 5% methoxymethoxygeranyl diphosphate, compared with 100% for the reaction of dimethylallyl diphosphate with isopentenyl diphosphate. Mutant Y81D yields methoxymethoxyfarnesyl diphosphate with high efficiency
-
?
methoxymethoxydimethylallyl diphosphate + isopentenyl diphosphate
methoxymethoxygeranyl diphosphate + diphosphate
-
-
yield is 1% methoxymethoxygeranyl diphosphate, compared with 100% for the reaction of dimethylallyl diphosphate with isopentenyl diphosphate
-
?
propoxygeranyl diphosphate + isopentenyl diphosphate
propoxyfarnesyl diphosphate + diphosphate
-
-
yield is 3% methoxymethoxygeranyl diphosphate, compared with 100% for the reaction of dimethylallyl diphosphate with isopentenyl diphosphate, and 63% yield for mutant Y81D, plus 6% of propoxygeranylgeranyl diphosphate
-
?
propoxygeranyl diphosphate + isopentenyl diphosphate
propoxyfarnesyl diphosphate + diphosphate
-
-
yield is 62% methoxymethoxygeranyl diphosphate, compared with 100% for the reaction of dimethylallyl diphosphate with isopentenyl diphosphate
-
?
additional information
?
-
-
in vitro, but not in vivo, enzyme shows additional geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
additional information
?
-
enzyme is able to produce farnesyl phosphate directly from geranyl phosphate, activity of farnesylgeranyltransferase
-
-
?
additional information
?
-
-
enzyme is able to produce farnesyl phosphate directly from geranyl phosphate, activity of farnesylgeranyltransferase
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + geranylgeranyl diphosphate
reaction of EC 2.5.1.29, the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate. Under environmental stresses, Haematococcus pluvialis accumulates large amounts of carotenoids. Scale of carotenoid biosynthesis depends on availability of geranylgeranyl pyrophosphate precursor, which is supplied by GGPP synthase through sequential 1'-4 condensation of three isopentenyl pyrophosphates into dimethylallyl pyrophosphate
-
-
?
2 dimethylallyl diphosphate
diphosphate + chrysanthemyl diphosphate
reaction of EC 2.5.1.67, chrysanthemyl diphosphate synthase is an inefficient promiscuous enzyme, which synthesizes the irregular monoterpenes chrysanthemyl diphosphate (CPP), lavandulyl diphosphate (LPP), and trace quantities of maconelliyl diphosphate (MPP) from two molecules of DMAPP, and couples IPP to DMAPP to give GPP
-
-
?
2 dimethylallyl diphosphate
diphosphate + lavandulyl diphosphate
reaction of EC 2.5.1.69, chrysanthemyl diphosphate synthase is an inefficient promiscuous enzyme, which synthesizes the irregular monoterpenes chrysanthemyl diphosphate (CPP), lavandulyl diphosphate (LPP), and trace quantities of maconelliyl diphosphate (MPP) from two molecules of DMAPP, and couples IPP to DMAPP to give GPP
-
-
?
dimethylallyl diphosphate + 2 isopentenyl diphosphate
2 diphosphate + farnesyl diphosphate
-
in the presence of Mg2+
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
diphosphate + geranyl diphosphate
dimethylallyl diphosphate + isopentenyl diphosphate
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2E,6E)-farnesyl diphosphate
additional information
?
-
-
in vitro, but not in vivo, enzyme shows additional geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
in the presence of Co2+
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
chrysanthemyl diphosphate synthase is an inefficient promiscuous enzyme, which synthesizes the irregular monoterpenes chrysanthemyl diphosphate (CPP), lavandulyl diphosphate (LPP), and trace quantities of maconelliyl diphosphate (MPP) from two molecules of DMAPP, and couples IPP to DMAPP to give GPP
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
the enzyme catalyzes the condensation of two molecules of isopentenyl diphosphate with dimethylallyl diphosphate to generate the C15 product (2E,6E)-farnesyl diphosphate
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
-
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
-
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
the enzyme catalyzes the condensation of two molecules of isopentenyl diphosphate with dimethylallyl diphosphate to generate the C15 product (2E,6E)-farnesyl diphosphate
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
highest catalytic efficiency
-
-
r
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
highest catalytic efficiency
-
-
r
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate. Under environmental stresses, Haematococcus pluvialis accumulates large amounts of carotenoids. Scale of carotenoid biosynthesis depends on availability of geranylgeranyl pyrophosphate precursor, which is supplied by GGPP synthase through sequential 1'-4 condensation of three isopentenyl pyrophosphates into dimethylallyl pyrophosphate
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
reaction of EC 2.5.1.1, the enzyme catalyzes the condensation of dimethylallyl pyrophosphate and isopentenyl pyrophosphate, forming geranyl pyrophosphate and then farnesyl pyrophosphate
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
the enzyme catalyses the sequential condensation of dimethylallyl diphosphate with isopentenyl diphosphate (IPP) and the resulting geranyl diphosphate (GPP) with another unit of IPP, eventually producing the 15-carbon isoprenoid farnesyl diphosphate
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
-
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
the enzyme is involved in the biosynthesis of the monoterpenoid precursors needed for formation of the defensive compound chrysomelidial. Geranyl diphosphate is needed for the de novo synthesis of the cyclopentanoid monoterpene iridoids, defensive compounds that are produced during the entire larval stage of Phaedon cochleariae
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + geranyl diphosphate
-
the enzyme catalyzes the sequential condensation of two molecules of isopentenyl diphosphate (IPP) with dimethylallyl diphosphate (DMAPP), producing geranyl diphosphate (GPP) and farnesyl diphosphate
-
-
?
diphosphate + geranyl diphosphate
dimethylallyl diphosphate + isopentenyl diphosphate
-
-
-
-
r
diphosphate + geranyl diphosphate
dimethylallyl diphosphate + isopentenyl diphosphate
-
-
-
-
r
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2E,6E)-farnesyl diphosphate
reaction of EC 2.5.1.10, the enzyme catalyzes the condensation of two molecules of isopentenyl diphosphate with dimethylallyl diphosphate to generate the C15 product (2E,6E)-farnesyl diphosphate
-
-
?
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2E,6E)-farnesyl diphosphate
reaction of EC 2.5.1.10, the enzyme catalyzes the condensation of two molecules of isopentenyl diphosphate with dimethylallyl diphosphate to generate the C15 product (2E,6E)-farnesyl diphosphate
-
-
?
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2E,6E)-farnesyl diphosphate
reaction of EC 2.5.1.10, the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate. Under environmental stresses, Haematococcus pluvialis accumulates large amounts of carotenoids. Scale of carotenoid biosynthesis depends on availability of geranylgeranyl pyrophosphate precursor, which is supplied by GGPP synthase through sequential 1'-4 condensation of three isopentenyl pyrophosphates into dimethylallyl pyrophosphate
-
-
?
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2E,6E)-farnesyl diphosphate
reaction of EC 2.5.1.10, the enzyme catalyzes the condensation of dimethylallyl pyrophosphate and isopentenyl pyrophosphate, forming geranyl pyrophosphate and then farnesyl pyrophosphate
-
-
?
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2E,6E)-farnesyl diphosphate
reaction of EC 2.5.1.10. The enzyme catalyses the sequential condensation of dimethylallyl diphosphate with isopentenyl diphosphate (IPP) and the resulting geranyl diphosphate (GPP) with another unit of IPP, eventually producing the 15-carbon isoprenoid farnesyl diphosphate
-
-
?
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2E,6E)-farnesyl diphosphate
-
reaction of EC 2.5.1.10. The enzyme catalyzes the sequential condensation of two molecules of isopentenyl diphosphate (IPP) with dimethylallyl diphosphate (DMAPP), producing geranyl diphosphate (GPP) and farnesyl diphosphate
-
-
?
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(4bR,8aS)-4b-(5-acetyl-1,3,4-oxadiazol-2-yl)-8,8-dimethyl-2-(propan-2-yl)-5,6,7,8,8a,9-hexahydrophenanthrene-3,4,10(4bH)-trione
-
(4bR,8aS)-4b-(5-amino-1,3,4-oxadiazol-2-yl)-8,8-dimethyl-2-(propan-2-yl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-3,4-diol
-
(4bR,8aS)-4b-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-8,8-dimethyl-2-(propan-2-yl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-3,4-diol
-
(4bR,8aS)-4b-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-8,8-dimethyl-2-(propan-2-yl)-5,6,7,8,8a,9-hexahydrophenanthrene-3,4,10(4bH)-trione
-
(4bR,8aS)-4b-(5-[(1S)-1-[(hydroxymethyl)amino]ethyl]-1,3,4-oxadiazol-2-yl)-8,8-dimethyl-2-(propan-2-yl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-3,4-diol
-
(4bR,8aS)-4b-[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]-8,8-dimethyl-2-(propan-2-yl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-3,4-diol
-
(4bR,8aS)-4b-[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]-8,8-dimethyl-2-(propan-2-yl)-5,6,7,8,8a,9-hexahydrophenanthrene-3,4,10(4bH)-trione
-
(4bR,8aS)-4b-[5-[(dimethylamino)methyl]-1,3,4-oxadiazol-2-yl]-8,8-dimethyl-2-(propan-2-yl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-3,4-diol
-
11,12-dihydroxy-7,20-epoxyabieta-8,11,13-trien-20-one
-
11,12-dihydroxy-N-(2-hydroxyethyl)abieta-8(14),9(11),12-trien-20-amide
-
11,12-dihydroxy-N-methylabieta-8(14),9(11),12-trien-20-amide
-
11,12-dihydroxy-N-[(pyridin-3-yl)methyl]abieta-8(14),9(11),12-trien-20-amide
-
11,12-dihydroxy-N-[3-(1H-imidazol-1-yl)propyl]abieta-8(14),9(11),12-trien-20-amide
-
11,12-dihydroxyabieta-8(14),9(11),12-triene-20-hydrazide
-
12-hydroxy-11,20-epoxyabieta-8(14),9(11),12-trien-20-one
-
2-[11,12-dihydroxy-20-oxoabieta-8(14),9(11),12-trien-20-yl]hydrazine-1-carboxamide
-
4-[5-[(4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-(propan-2-yl)-1,3,4,9,10,10a-hexahydrophenanthren-4a(2H)-yl]-1,3,4-oxadiazol-2-yl]benzonitrile
-
6,20-epoxyabieta-8,13-diene-7,11,12,20-tetrone
-
7,20-epoxyabieta-8(14),9(11),12-triene-11,12-diol
-
7,20-epoxyabieta-8,13-diene-11,12,20-trione
-
7,20-epoxyabieta-8,13-diene-11,12-dione
-
abieta-8(14),9(11),12-triene-11,12,20-triol
-
farnesyl diphosphate
allosteric product inhibition. the product can trap the enzyme in an unreactive state by binding to its allosteric pocket
isopentenyl diphosphate
-
substrate inhibition
methyl 11,12-dihydroxy-7-(phenylsulfanyl)abieta-8(14),9(11),12-trien-20-oate
-
methyl 11,12-dihydroxy-7-methoxyabieta-8(14),9(11),12-trien-20-oate
-
methyl 11,12-dihydroxy-7-oxoabieta-8(14),9(11),12-trien-20-oate
-
methyl 11,12-dihydroxy-7-[(2-hydroxyethyl)sulfanyl]abieta-8(14),9(11),12-trien-20-oate
-
methyl 11,12-dihydroxyabieta-7,9(11),13-trien-20-oate
-
methyl 11,12-dihydroxyabieta-8(14),9(11),12-trien-20-oate
-
methyl 11-[[tert-butyl(dimethyl)silyl]oxy]-12-hydroxyabieta-8(14),9(11),12-trien-20-oate
-
methyl 7,11,12-trioxoabieta-8,13-dien-20-oate
-
methyl 7-(butylsulfanyl)-11,12-dihydroxyabieta-8(14),9(11),12-trien-20-oate
-
methyl 7-ethoxy-11,12-dihydroxyabieta-8(14),9(11),12-trien-20-oate
-
methyl 7-ethoxy-11,12-dioxoabieta-8,13-dien-20-oate
-
methyl 7-tert-butoxy-11,12-dioxoabieta-8,13-dien-20-oate
-
methyl 7-[(2-hydroxyethyl)sulfanyl]-11,12-dioxoabieta-8,13-dien-20-oate
-
N'-(4-bromobenzoyl)-11,12-dihydroxyabieta-8(14),9(11),12-triene-20-hydrazide
-
N'-acetyl-11,12-dihydroxyabieta-8(14),9(11),12-triene-20-hydrazide
-
N-acetyl-S-((4aR,10aS)-5,6-dihydroxy-7-isopropyl-4a-(methoxycarbonyl)-1,1-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-9-yl)-L-cysteine
-
N-benzyl-11,12-dihydroxyabieta-8(14),9(11),12-trien-20-amide
-
N-[2-(dimethylamino)ethyl]-11,12-dihydroxy-7-oxoabieta-8(14),9(11),12-trien-20-amide
-
N-[2-(dimethylamino)ethyl]-11,12-dihydroxyabieta-8(14),9(11),12-trien-20-amide
-
tert-butyl [(1R)-1-amino-2-[2-[11,12-dihydroxy-20-oxoabieta-8(14),9(11),12-trien-20-yl]hydrazinyl]-2-oxoethyl]carbamate
-
tert-butyl [(1R)-1-[5-[(4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-9-oxo-7-(propan-2-yl)-1,3,4,9,10,10a-hexahydrophenanthren-4a(2H)-yl]-1,3,4-oxadiazol-2-yl]ethyl]carbamate
-
tert-butyl [(1S)-1-[5-[(4aR,10aS)-1,1-dimethyl-5,6,9-trioxo-7-(propan-2-yl)-1,3,4,5,6,9,10,10a-octahydrophenanthren-4a(2H)-yl]-1,3,4-oxadiazol-2-yl]ethyl]carbamate
-
tert-butyl [(1S)-1-[5-[(4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-(propan-2-yl)-1,3,4,9,10,10a-hexahydrophenanthren-4a(2H)-yl]-1,3,4-oxadiazol-2-yl]ethyl]carbamate
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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0.000289
(4bR,8aS)-4b-(5-acetyl-1,3,4-oxadiazol-2-yl)-8,8-dimethyl-2-(propan-2-yl)-5,6,7,8,8a,9-hexahydrophenanthrene-3,4,10(4bH)-trione
Homo sapiens
pH 7.5, 23°C
0.000859
(4bR,8aS)-4b-(5-amino-1,3,4-oxadiazol-2-yl)-8,8-dimethyl-2-(propan-2-yl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-3,4-diol
Homo sapiens
pH 7.5, 23°C
0.0022
(4bR,8aS)-4b-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-8,8-dimethyl-2-(propan-2-yl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-3,4-diol
Homo sapiens
pH 7.5, 23°C
0.000335
(4bR,8aS)-4b-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-8,8-dimethyl-2-(propan-2-yl)-5,6,7,8,8a,9-hexahydrophenanthrene-3,4,10(4bH)-trione
Homo sapiens
pH 7.5, 23°C
0.000194
(4bR,8aS)-4b-(5-[(1S)-1-[(hydroxymethyl)amino]ethyl]-1,3,4-oxadiazol-2-yl)-8,8-dimethyl-2-(propan-2-yl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-3,4-diol
Homo sapiens
pH 7.5, 23°C
0.0251
(4bR,8aS)-4b-[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]-8,8-dimethyl-2-(propan-2-yl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-3,4-diol
Homo sapiens
pH 7.5, 23°C
0.0137
(4bR,8aS)-4b-[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]-8,8-dimethyl-2-(propan-2-yl)-5,6,7,8,8a,9-hexahydrophenanthrene-3,4,10(4bH)-trione
Homo sapiens
pH 7.5, 23°C
0.0011
(4bR,8aS)-4b-[5-[(dimethylamino)methyl]-1,3,4-oxadiazol-2-yl]-8,8-dimethyl-2-(propan-2-yl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-3,4-diol
Homo sapiens
pH 7.5, 23°C
0.0133
11,12-dihydroxy-7,20-epoxyabieta-8,11,13-trien-20-one
Homo sapiens
pH 7.5, 23°C
0.000914
11,12-dihydroxy-N-(2-hydroxyethyl)abieta-8(14),9(11),12-trien-20-amide
Homo sapiens
pH 7.5, 23°C
0.0027
11,12-dihydroxy-N-methylabieta-8(14),9(11),12-trien-20-amide
Homo sapiens
pH 7.5, 23°C
0.0027
11,12-dihydroxy-N-[(pyridin-3-yl)methyl]abieta-8(14),9(11),12-trien-20-amide
Homo sapiens
pH 7.5, 23°C
0.008
11,12-dihydroxy-N-[3-(1H-imidazol-1-yl)propyl]abieta-8(14),9(11),12-trien-20-amide
Homo sapiens
pH 7.5, 23°C
0.035
11,12-dihydroxyabieta-8(14),9(11),12-triene-20-hydrazide
Homo sapiens
pH 7.5, 23°C
0.0106
12-hydroxy-11,20-epoxyabieta-8(14),9(11),12-trien-20-one
Homo sapiens
pH 7.5, 23°C
0.0031
2-[11,12-dihydroxy-20-oxoabieta-8(14),9(11),12-trien-20-yl]hydrazine-1-carboxamide
Homo sapiens
pH 7.5, 23°C
0.0074
4-[5-[(4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-(propan-2-yl)-1,3,4,9,10,10a-hexahydrophenanthren-4a(2H)-yl]-1,3,4-oxadiazol-2-yl]benzonitrile
Homo sapiens
pH 7.5, 23°C
0.000389
6,20-epoxyabieta-8,13-diene-7,11,12,20-tetrone
Homo sapiens
pH 7.5, 23°C
0.0187
7,20-epoxyabieta-8(14),9(11),12-triene-11,12-diol
Homo sapiens
pH 7.5, 23°C
0.000473
7,20-epoxyabieta-8,13-diene-11,12,20-trione
Homo sapiens
pH 7.5, 23°C
0.000596
7,20-epoxyabieta-8,13-diene-11,12-dione
Homo sapiens
pH 7.5, 23°C
0.0078
abieta-8(14),9(11),12-triene-11,12,20-triol
Homo sapiens
pH 7.5, 23°C
0.028
methyl 11,12-dihydroxy-7-(phenylsulfanyl)abieta-8(14),9(11),12-trien-20-oate
Homo sapiens
pH 7.5, 23°C
0.0011
methyl 11,12-dihydroxy-7-methoxyabieta-8(14),9(11),12-trien-20-oate
Homo sapiens
pH 7.5, 23°C
0.0412
methyl 11,12-dihydroxy-7-oxoabieta-8(14),9(11),12-trien-20-oate
Homo sapiens
pH 7.5, 23°C
0.0013
methyl 11,12-dihydroxy-7-[(2-hydroxyethyl)sulfanyl]abieta-8(14),9(11),12-trien-20-oate
Homo sapiens
pH 7.5, 23°C
0.000833
methyl 11,12-dihydroxyabieta-7,9(11),13-trien-20-oate
Homo sapiens
pH 7.5, 23°C
0.000865
methyl 11,12-dihydroxyabieta-8(14),9(11),12-trien-20-oate
Homo sapiens
pH 7.5, 23°C
0.0563
methyl 11-[[tert-butyl(dimethyl)silyl]oxy]-12-hydroxyabieta-8(14),9(11),12-trien-20-oate
Homo sapiens
pH 7.5, 23°C
0.000523
methyl 7,11,12-trioxoabieta-8,13-dien-20-oate
Homo sapiens
pH 7.5, 23°C
0.0125
methyl 7-(butylsulfanyl)-11,12-dihydroxyabieta-8(14),9(11),12-trien-20-oate
Homo sapiens
pH 7.5, 23°C
0.0133
methyl 7-ethoxy-11,12-dihydroxyabieta-8(14),9(11),12-trien-20-oate
Homo sapiens
pH 7.5, 23°C
0.0086
methyl 7-ethoxy-11,12-dioxoabieta-8,13-dien-20-oate
Homo sapiens
pH 7.5, 23°C
0.000234
methyl 7-tert-butoxy-11,12-dioxoabieta-8,13-dien-20-oate
Homo sapiens
pH 7.5, 23°C
0.0227
methyl 7-[(2-hydroxyethyl)sulfanyl]-11,12-dioxoabieta-8,13-dien-20-oate
Homo sapiens
pH 7.5, 23°C
0.0008
N'-(4-bromobenzoyl)-11,12-dihydroxyabieta-8(14),9(11),12-triene-20-hydrazide
Homo sapiens
pH 7.5, 23°C
0.0015
N'-acetyl-11,12-dihydroxyabieta-8(14),9(11),12-triene-20-hydrazide
Homo sapiens
pH 7.5, 23°C
0.02564
N-acetyl-S-((4aR,10aS)-5,6-dihydroxy-7-isopropyl-4a-(methoxycarbonyl)-1,1-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-9-yl)-L-cysteine
Homo sapiens
pH 7.5, 23°C
0.00603
N-benzyl-11,12-dihydroxyabieta-8(14),9(11),12-trien-20-amide
Homo sapiens
pH 7.5, 23°C
0.008
N-[2-(dimethylamino)ethyl]-11,12-dihydroxy-7-oxoabieta-8(14),9(11),12-trien-20-amide
Homo sapiens
pH 7.5, 23°C
0.0012
N-[2-(dimethylamino)ethyl]-11,12-dihydroxyabieta-8(14),9(11),12-trien-20-amide
Homo sapiens
pH 7.5, 23°C
0.00052
tert-butyl [(1R)-1-amino-2-[2-[11,12-dihydroxy-20-oxoabieta-8(14),9(11),12-trien-20-yl]hydrazinyl]-2-oxoethyl]carbamate
Homo sapiens
pH 7.5, 23°C
0.0125
tert-butyl [(1R)-1-[5-[(4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-9-oxo-7-(propan-2-yl)-1,3,4,9,10,10a-hexahydrophenanthren-4a(2H)-yl]-1,3,4-oxadiazol-2-yl]ethyl]carbamate
Homo sapiens
pH 7.5, 23°C
0.000252
tert-butyl [(1S)-1-[5-[(4aR,10aS)-1,1-dimethyl-5,6,9-trioxo-7-(propan-2-yl)-1,3,4,5,6,9,10,10a-octahydrophenanthren-4a(2H)-yl]-1,3,4-oxadiazol-2-yl]ethyl]carbamate
Homo sapiens
pH 7.5, 23°C
0.000644
tert-butyl [(1S)-1-[5-[(4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-(propan-2-yl)-1,3,4,9,10,10a-hexahydrophenanthren-4a(2H)-yl]-1,3,4-oxadiazol-2-yl]ethyl]carbamate
Homo sapiens
pH 7.5, 23°C
0.0001
zoledronate
Homo sapiens
pH 7.5, 23°C
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Vandermoten, S.; Santini, S.; Haubruge, E.; Heuze, F.; Francis, F.; Brasseur, R.; Cusson, M.; Charloteaux, B.
Structural features conferring dual geranyl/farnesyl diphosphate synthase activity to an aphid prenyltransferase
Insect Biochem. Mol. Biol.
39
707-716
2009
Acyrthosiphon pisum (Q1X877)
brenda
Lewis, M.J.; Prosser, I.M.; Mohib, A.; Field, L.M.
Cloning and characterisation of a prenyltransferase from the aphid Myzus persicae with potential involvement in alarm pheromone biosynthesis
Insect Mol. Biol.
17
437-443
2008
Myzus persicae (Q1X876), Myzus persicae
brenda
Nagaki, M.; Musashi, T.; Hirano, Y.; Tanaka, H.; Ichita, J.; Maki, Y.; Koyama, T.
Substrate specificities of farnesyl diphosphate synthases of Bacillus stearothermophilus and porcine liver with allylic substrate homologs having vinyl or ethynyl group
J. Mol. Catal. B
59
163-167
2009
Sus scrofa
-
brenda
Nagaki, M.; Nakada, M.; Musashi, T.; Kawakami, J.; Endo, T.; Maki, Y.; Koyama, T.
Substrate specificities of wild and mutated farnesyl diphosphate synthases: Reactivity of allylic substrate homologs having hydrophilic groups at omega-position
J. Mol. Catal. B
59
225-230
2009
Geobacillus stearothermophilus, Sus scrofa
-
brenda
Nagaki, M.; Kanno, H.; Musashi, T.; Shimizu, R.; Maki, Y.; Sagami, H.; Koyama, T.
Substrate specificities of farnesyl diphosphate synthases from Bacillus stearothermophilus and porcine liver with cyclic substrate homologs
J. Mol. Catal. B
60
186-190
2009
Geobacillus stearothermophilus, Sus scrofa
-
brenda
Gilg, A.B.; Tittiger, C.; Blomquist, G.J.
Unique animal prenyltransferase with monoterpene synthase activity
Naturwissenschaften
96
731-735
2009
Ips pini (Q58GE8), Ips pini
brenda
Chang, T.H.; Hsieh, F.L.; Ko, T.P.; Teng, K.H.; Liang, P.H.; Wang, A.H.
Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation
Plant Cell
22
454-467
2010
Mentha x piperita
brenda
Schmidt, A.; Waechtler, B.; Temp, U.; Krekling, T.; Seguin, A.; Gershenzon, J.
A bifunctional geranyl and geranylgeranyl diphosphate synthase is involved in terpene oleoresin formation in Picea abies
Plant Physiol.
152
639-655
2010
Picea abies (D2IT07), Picea abies
brenda
Mann, F.M.; Thomas, J.A.; Peters, R.J.
Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis
FEBS Lett.
585
549-554
2011
Mycobacterium tuberculosis, Mycobacterium tuberculosis CDC 1551
brenda
Nagegowda, D.
The small subunit of geranyl diphosphate synthase: A tool to improve aroma and flavour by metabolic engineering
J. Biosci.
35
167-169
2010
Antirrhinum majus, Clarkia breweri (Q6QLU5), Mentha x piperita (Q9SBR4)
brenda
Schmidt, A.; Nagel, R.; Krekling, T.; Christiansen, E.; Gershenzon, J.; Krokene, P.
Induction of isoprenyl diphosphate synthases, plant hormones and defense signalling genes correlates with traumatic resin duct formation in Norway spruce (Picea abies)
Plant Mol. Biol.
77
577-590
2011
Picea abies
brenda
Frick, S.; Nagel, R.; Schmidt, A.; Bodemann, R.R.; Rahfeld, P.; Pauls, G.; Brandt, W.; Gershenzon, J.; Boland, W.; Burse, A.
Metal ions control product specificity of isoprenyl diphosphate synthases in the insect terpenoid pathway
Proc. Natl. Acad. Sci. USA
110
4194-4199
2013
Phaedon cochleariae
brenda
Zhou, J.; Wang, X.; Kuang, M.; Wang, L.; Luo, H.; Mo, Y.; Wu, R.
Protonation-triggered carbon-chain elongation in geranyl pyrophosphate synthase (GPPS)
ACS Catal.
5
4466-4478
2015
Mentha x piperita (Q9SBR3 and Q9SBR4)
-
brenda
Pockrandt, D.; Li, S.M.
Geranylation of cyclic dipeptides by the dimethylallyl transferase AnaPT resulting in a shift of prenylation position on the indole ring
ChemBioChem
14
2023-2028
2013
Aspergillus fischeri
brenda
Heider, S.A.; Peters-Wendisch, P.; Beekwilder, J.; Wendisch, V.F.
IdsA is the major geranylgeranyl pyrophosphate synthase involved in carotenogenesis in Corynebacterium glutamicum
FEBS J.
281
4906-4920
2014
Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 13032
brenda
Rivera-Perez, C.; Nyati, P.; Noriega, F.G.
A corpora allata farnesyl diphosphate synthase in mosquitoes displaying a metal ion dependent substrate specificity
Insect Biochem. Mol. Biol.
64
44-50
2015
Aedes aegypti (Q17F78)
brenda
Liu, Z.; Zhou, J.; Wu, R.; Xu, J.
Mechanism of assembling isoprenoid building blocks 1. elucidation of the structural motifs for substrate binding in geranyl pyrophosphate synthase
J. Chem. Theory Comput.
10
5057-5067
2014
Mentha x piperita (Q9SBR3 and Q9SBR4)
brenda
Rai, A.; Smita, S.S.; Singh, A.K.; Shanker, K.; Nagegowda, D.A.
Heteromeric and homomeric geranyl diphosphate synthases from Catharanthus roseus and their role in monoterpene indole alkaloid biosynthesis
Mol. Plant
6
1531-1549
2013
Catharanthus roseus (B2MV87), Catharanthus roseus
brenda
Liebhold, M.; Li, S.M.
Regiospecific benzylation of tryptophan and derivatives catalyzed by a fungal dimethylallyl transferase
Org. Lett.
15
5834-5837
2013
Aspergillus fumigatus
brenda
Xi, J.; Rossi, L.; Lin, X.; Xie, D.Y.
Overexpression of a synthetic insect-plant geranyl pyrophosphate synthase gene in Camelina sativa alters plant growth and terpene biosynthesis
Planta
244
215-230
2016
Myzus persicae
brenda
Keeling, C.I.; Chiu, C.C.; Aw, T.; Li, M.; Henderson, H.; Tittiger, C.; Weng, H.B.; Blomquist, G.J.; Bohlmann, J.
Frontalin pheromone biosynthesis in the mountain pine beetle, Dendroctonus ponderosae, and the role of isoprenyl diphosphate synthases
Proc. Natl. Acad. Sci. USA
110
18838-18843
2013
Dendroctonus ponderosae (I1VJ84), Dendroctonus ponderosae
brenda
Yang, L.; Jiang, L.; Li, W.; Yang, Y.; Zhang, G.; Luo, Y.
A homomeric geranyl diphosphate synthase-encoding gene from Camptotheca acuminata and its combinatorial optimization for production of geraniol in Escherichia coli
J. Ind. Microbiol. Biotechnol.
44
1431-1441
2017
Camptotheca acuminata (A0A2H4ULH9), Camptotheca acuminata
brenda
Rubat, S.; Varas, I.; Sepulveda, R.; Almonacid, D.; Gonzalez-Nilo, F.; Agosin, E.
Increasing the intracellular isoprenoid pool in Saccharomyces cerevisiae by structural fine-tuning of a bifunctional farnesyl diphosphate synthase
FEMS Yeast Res.
17
fox032
2017
Saccharomyces cerevisiae
brenda
Picard, M.E.; Nisole, A.; Beliveau, C.; Sen, S.; Barbar, A.; Shi, R.; Cusson, M.
Structural characterization of a lepidopteran type-II farnesyl diphosphate synthase from the spruce budworm, Choristoneura fumiferana Implications for inhibitor design
Insect Biochem. Mol. Biol.
92
84-92
2018
Choristoneura fumiferana (Q1XAB1)
brenda
Lee, J.S.; Pan, J.J.; Ramamoorthy, G.; Poulter, C.D.
Structure-function studies of Artemisia tridentata farnesyl diphosphate synthase and chrysanthemyl diphosphate synthase by site-directed mutagenesis and morphogenesis
J. Am. Chem. Soc.
139
14556-14567
2017
Artemisia spiciformis, Artemisia spiciformis (Q7XYS8)
brenda
Han, S.; Li, X.; Xia, Y.; Yu, Z.; Cai, N.; Malwal, S.R.; Han, X.; Oldfield, E.; Zhang, Y.
Farnesyl pyrophosphate synthase as a target for drug development discovery of natural-product-derived inhibitors and their activity in pancreatic cancer cells
J. Med. Chem.
62
10867-10896
2019
Homo sapiens (P14324)
brenda
Barja, M.V.; Rodriguez-Concepcion, M.
A Simple In vitro assay to measure the activity of geranylgeranyl diphosphate synthase and other short-chain prenyltransferases
Methods Mol. Biol.
2083
27-38
2020
Arabidopsis thaliana (P34802)
brenda
Park, J.; Zielinski, M.; Magder, A.; Tsantrizos, Y.S.; Berghuis, A.M.
Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product
Nat. Commun.
8
14132
2017
Homo sapiens (P14324)
brenda
Lao, Y.M.; Jin, H.; Zhou, J.; Zhang, H.J.; Zhu, X.S.; Cai, Z.H.
A Novel Hydrolytic Activity of Tri-Functional Geranylgeranyl Pyrophosphate Synthase in Haematococcus pluvialis
Plant Cell Physiol.
59
2536-2548
2018
Haematococcus lacustris (A0A0K0TQ44), Haematococcus lacustris
brenda