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Information on EC 2.1.1.114 - polyprenyldihydroxybenzoate methyltransferase

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IUBMB Comments
This enzyme is involved in ubiquinone biosynthesis. Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone-9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units. For example, the human COQ3 enzyme can restore biosynthesis of ubiquinone-6 in coq3 deletion mutants of yeast . The enzymes from yeast and rat also catalyse the methylation of 3-demethylubiquinol-6 and 3-demethylubiquinol-9, respectively (this activity is classified as EC 2.1.1.64, 3-demethylubiquinol 3-O-methyltransferase).
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Word Map
  • 2.1.1.114
  • ubiquinone
  • nonfermentable
  • co-migrate
  • multi-subunit
  • q-deficient
  • peripherally
  • elegans
  • native-page
  • digitonin-solubilized
  • quinone
  • p-hydroxybenzoic
  • worms
  • isoprenoid
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
coq3p, coq-3, coq3 o-methyltransferase, dhhb methyltransferase, dhhb-mtase, 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase, atcoq3, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate
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