Literature summary for 2.1.1.114 extracted from

Poon, W.W.; Barkovich, R.J.; Hsu, A.Y.; Frankel, A.; Lee, P.T.; Sheperd, J.N.; Myles, D.C.; Clarke, C.F.
Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis (1999), J. Biol. Chem., 274, 21665-21672.

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Cloned(Commentary)

Cloned (Comment)	Organism
rat COQ3 gene restores O-methyltransferase activity in coq3 null mutant yeast	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	the Coq3 polypeptide is peripherally associated with the matrix side of the inner membrane of yeast mitochondria	Saccharomyces cerevisiae	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + 3,4-dihydroxy-5-hexaprenylbenzoate	Saccharomyces cerevisiae	the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-6, 1. the methylation of 3,4-dihydroxy-5-hexaprenylbenzoate and 2. the methylation of 3-demethylubiquinol-6 (this reaction is classified as EC 2.1.1.64)	S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-hexaprenylbenzoate	-	?
S-adenosyl-L-methionine + 3,4-dihydroxy-5-octaprenylbenzoate	Rattus norvegicus	the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-8, 1. the methylation of 3,4-dihydroxy-5-octaprenylbenzoate and 2. the methylation of 3-demethylubiquinol-8 (this reaction is classified as EC 2.1.1.64)	S-adenosyl-L-homocysteine + 4-hydroxy-3-methoxy-5-octaprenylbenzoate	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	Q63159	-	-
Saccharomyces cerevisiae	P27680	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + 3,4-dihydroxy-5-((2E,6E)-farnesyl)benzoate	-	Rattus norvegicus	S-adenosyl-L-homocysteine + 5-((2E,6E)-farnesyl)-4-hydroxy-3-methoxybenzoate	-	?
S-adenosyl-L-methionine + 3,4-dihydroxy-5-(2E,6E)-farnesylbenzoate	-	Saccharomyces cerevisiae	S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-farnesylbenzoate	-	?
S-adenosyl-L-methionine + 3,4-dihydroxy-5-hexaprenylbenzoate	the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-6, 1. the methylation of 3,4-dihydroxy-5-hexaprenylbenzoate and 2. the methylation of 3-demethylubiquinol-6 (this reaction is classified as EC 2.1.1.64)	Saccharomyces cerevisiae	S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-hexaprenylbenzoate	-	?
S-adenosyl-L-methionine + 3,4-dihydroxy-5-octaprenylbenzoate	the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-8, 1. the methylation of 3,4-dihydroxy-5-octaprenylbenzoate and 2. the methylation of 3-demethylubiquinol-8 (this reaction is classified as EC 2.1.1.64)	Rattus norvegicus	S-adenosyl-L-homocysteine + 4-hydroxy-3-methoxy-5-octaprenylbenzoate	-	?

Synonyms

Synonyms	Comment	Organism
Coq3p	-	Saccharomyces cerevisiae
Coq3p	-	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7	-	assay at	Saccharomyces cerevisiae
7	-	assay at	Rattus norvegicus

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Release 2023.1 (January 2023)