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Information on EC 1.4.1.25 - L-arginine dehydrogenase
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The expected taxonomic range for this enzyme is: Pseudomonas aeruginosa
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EC NUMBER 
COMMENTARY 
1.4.1.25
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RECOMMENDED NAME
GeneOntology No.
L-arginine dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
L-arginine + H2O + NAD(P)+ = 5-guanidino-2-oxopentanoate + NH3 + NAD(P)H + H+
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
L-arginine:NAD(P)+ oxidoreductase (deaminating)
The enzyme, which has been isolated from the bacterium Pseudomonas aeruginosa PAO1, forms with EC 1.4.99.6, D-arginine dehydrogenase, a two-enzyme complex involved in the racemization of D- and L-arginine.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
physiological function
strains with a lesion at DauA or DauB genes fail to use D-arginine as sole carbon source. Growth complementation of an L-arginine auxotroph by D-arginine is abolished by a lesion at DauA or DauB. Presence of D-arginine induces L-arginine-specific genes in the parental strain PAO1 but not in its dauA or dauB mutants. DauA catalyzes oxidative deamination of D-arginine into 2-ketoarginine and ammonia, and DauB is able to use 2-ketoarginine and ammonia as substrates and convert them into L-arginine in the presence of NADPH or NADH
physiological function
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strains with a lesion at DauA or DauB genes fail to use D-arginine as sole carbon source. Growth complementation of an L-arginine auxotroph by D-arginine is abolished by a lesion at DauA or DauB. Presence of D-arginine induces L-arginine-specific genes in the parental strain PAO1 but not in its dauA or dauB mutants. DauA catalyzes oxidative deamination of D-arginine into 2-ketoarginine and ammonia, and DauB is able to use 2-ketoarginine and ammonia as substrates and convert them into L-arginine in the presence of NADPH or NADH
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
5-guanidino-2-oxopentanoate + NH3 + NAD(P)H + H+
L-arginine + H2O + NAD(P)+
DauB uses 2-ketoarginine and ammonia derived from D-arginine in the DauA-catalyzed reaction
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?
5-guanidino-2-oxopentanoate + NH3 + NAD(P)H + H+
L-arginine + H2O + NAD(P)+
DauB uses 2-ketoarginine and ammonia derived from D-arginine in the DauA-catalyzed reaction
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?
L-arginine + H2O + NAD(P)+
5-guanidino-2-oxopentanoate + NH3 + NAD(P)H + H+
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r
L-arginine + H2O + NAD(P)+
5-guanidino-2-oxopentanoate + NH3 + NAD(P)H + H+
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r
additional information
?
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no substantial reaction with D-arginine
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additional information
?
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no substantial reaction with D-arginine
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
expression of the DauBAR operon is highly induced in presence of D-arginine
expression of the DauBAR operon is highly induced in presence of D-arginine
expression of the DauBAR operon is highly induced in presence of D-arginine
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LINKS TO OTHER DATABASES (specific for EC-Number 1.4.1.25)
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