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IUBMB Comments Last step in the cyclohexanol degradation pathway in Acinetobacter sp.
Synonyms
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6-oxohexanoate dehydrogenase
6-oxohexanoate dehydrogenase
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6-oxohexanoate dehydrogenase
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6-oxohexanoate + NADP+ + H2O = adipate + NADPH + H+
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MetaCyc
cyclohexanol degradation, nylon-6 oligomer degradation
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6-oxohexanoate:NADP+ oxidoreductase
Last step in the cyclohexanol degradation pathway in Acinetobacter sp.
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6-oxohexanoate + NADP+ + H2O
adipate + NADPH
additional information
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6-oxohexanoate + NADP+ + H2O
adipate + NADPH
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Substrates: -
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6-oxohexanoate + NADP+ + H2O
adipate + NADPH
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Substrates: -
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6-oxohexanoate + NADP+ + H2O
adipate + NADPH
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Substrates: -
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6-oxohexanoate + NADP+ + H2O
adipate + NADPH
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Substrates: -
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Substrates: together with 2-oxoglutarate-6-aminohexanoate transaminase, 6-oxohexanoate dehydrogenase degrades caprolactam to adipate
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Substrates: together with 2-oxoglutarate-6-aminohexanoate transaminase, 6-oxohexanoate dehydrogenase degrades caprolactam to adipate
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6-oxohexanoate + NADP+ + H2O
adipate + NADPH
6-oxohexanoate + NADP+ + H2O
adipate + NADPH
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Substrates: -
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6-oxohexanoate + NADP+ + H2O
adipate + NADPH
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Substrates: -
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6-oxohexanoate + NADP+ + H2O
adipate + NADPH
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Substrates: -
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6-oxohexanoate + NADP+ + H2O
adipate + NADPH
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Substrates: -
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NADP+
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NADP+
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can not replaced by NAD+
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plasmid-bearing strain with CAP biodegradation plasmid
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plasmid-bearing strain with CAP biodegradation plasmid
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inducible enzyme synthesis by growth in cyclohexanol
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strain TD63 only inducible for enzyme synthesis in the presence of trans-cyclohexan-1,2-diol-containing growth media
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inducible enzyme synthesis by growth in cyclohexanol
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strain TD63 only inducible for enzyme synthesis in the presence of trans-cyclohexan-1,2-diol-containing growth media
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strain TD63 only inducible for enzyme synthesis in the presence of trans-cyclohexan-1,2-diol-containing growth media
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inducible enzyme synthesis by growth in cyclohexanol
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inducible enzyme synthesis by growth in cyclohexanol
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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metabolism
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enzyme is involved in aerobic degradation of linear caprolactam oligomers
metabolism
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enzyme is involved in aerobic degradation of linear caprolactam oligomers
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A0A4Y1MU47_9PROT
477
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51302
TrEMBL
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E5AUR8_MYCRK
Mycetohabitans rhizoxinica (strain DSM 19002 / CIP 109453 / HKI 454)
481
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50711
TrEMBL
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Q0RWL6_RHOJR
Rhodococcus jostii (strain RHA1)
457
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49359
TrEMBL
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diagnostics
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development of a biosensor for detection of caprolactam oligomers in aqueous media
diagnostics
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development of a biosensor for detection of caprolactam oligomers in aqueous media
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Davey, J.F.; Trudgill, P.W.
The metabolism of trans-cyclohexan-1,2-diol by an Acinetobacter species
Eur. J. Biochem.
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115-127
1977
Acinetobacter sp., Acinetobacter sp. NCIB 9871, Acinetobacter sp. TD63, Nocardia globerula, Nocardia globerula CL1
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Donoghue, N.A.; Trudgill, P.W.
The metabolism of cyclohexanol by Acinetobacter NCIB 9871
Eur. J. Biochem.
60
1-7
1975
Acinetobacter sp., Acinetobacter sp. NCIB 9871, Nocardia globerula, Nocardia globerula CL1
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Iwaki, H.; Hasegawa, Y.; Teraoka, M.; Tokuyama, T.; Bergeron, H.; Lau, P.C.K.
Identification of a transcriptional activator (ChnR) and a 6-oxohexanoate dehydrogenase (ChnE) in the cyclohexanol catabolic pathway in Acinetobacter sp. strain NCIMB 9871 and localization of the genes that encode them
Appl. Environ. Microbiol.
65
5158-5162
1999
Acinetobacter sp., Acinetobacter sp. NCIB 9871
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Esikova, T.; Ponamoreva, O.; Baskunov, B.; Taran, S.; Boronin, A.
Transformation of low-molecular linear caprolactam oligomers by caprolactam-degrading bacteria
J. Chem. Technol. Biotechnol.
87
1284-1290
2012
Pseudomonas putida, Pseudomonas putida BS394(pBS268)
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