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Information on EC 1.14.14.88 - isoflavone 3'-hydroxylase

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IUBMB Comments
A heme-thiolate protein (P-450). Also acts on biochanin A and other isoflavones with a 4'-methoxy group. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain.
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Word Map
  • 1.14.14.88
  • x-linked
  • dehydrogenase-like
  • nevus
  • hemidysplasia
  • sterol
  • ichthyosiform
  • ipsilateral
  • striated
  • intellectual
  • hypomorphic
  • midline
  • male-lethal
  • 3beta-hydroxysterol
  • demarcation
  • x-chromosomal
  • acronym
  • astragalus
  • erythematous
  • midgestation
  • membranaceus
  • x-inactivation
  • cholesterogenic
  • calycosin
  • 3\'-hydroxylase
  • mongholicus
  • hsiao
  • blaschko
  • medicine
The enzyme appears in viruses and cellular organisms
Synonyms
I3'H, isoflavone 3'-hydroxylase, isoflavone 3'-monooxygenase, MtCYP81E9, Mtl3'H, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
formononetin + [reduced NADPH-hemoprotein reductase] + O2 = calycosin + [oxidized NADPH-hemoprotein reductase] + H2O
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