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Information on EC - L-ornithine N5-monooxygenase [NAD(P)H]

for references in articles please use BRENDA:EC1.14.13.196
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IUBMB Comments
A flavoprotein (FAD). The enzyme from the pathogenic fungus Aspergillus fumigatus catalyses a step in the biosynthesis of the siderophores triacetylfusarinine and desferriferricrocin, while the enzyme from the bacterium Kutzneria sp. 744 is involved in the biosynthesis of piperazate, a building block of the kutzneride family of antifungal antibiotics. Activity of the fungal enzyme is higher with NADPH, due to the fact that following the reduction of the flavin, NADP+ (but not NAD+) stabilizes the C4a-hydroperoxyflavin intermediate that oxidizes the substrate . cf. EC, L-ornithine N5-monooxygenase (NADPH).
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
abachelin monooxygenase, AfSidA, AMO, SidA, siderophore A, more
L-ornithine + NAD(P)H + H+ + O2 = N5-hydroxy-L-ornithine + NAD(P)+ + H2O
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