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Information on EC 1.14.13.179 - methylxanthine N3-demethylase

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IUBMB Comments
A non-heme iron oxygenase. The enzyme from the bacterium Pseudomonas putida shares an NAD(P)H-FMN reductase subunit with EC 1.14.13.178, methylxanthine N1-demethylase, and has higher activity with NADH than with NADPH . Also demethylates caffeine and theophylline with lower efficiency. Forms part of the degradation pathway of methylxanthines.
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The expected taxonomic range for this enzyme is: Pseudomonas putida
Synonyms
ndmB, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3-methylxanthine + O2 + NAD(P)H + H+ = xanthine + NAD(P)+ + H2O + formaldehyde
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theobromine + O2 + NAD(P)H + H+ = 7-methylxanthine + NAD(P)+ + H2O + formaldehyde
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