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Information on EC 1.13.11.37 - hydroxyquinol 1,2-dioxygenase
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EC Tree
1.13.11.37 hydroxyquinol 1,2-dioxygenaseIUBMB Comments
An iron protein. Highly specific; catechol and pyrogallol are acted on at less than 1% of the rate at which hydroxyquinol is oxidized.
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Word Map
- 1.13.11.37
- maleylacetate
- catechols
- arthrobacter
-
ortho
-
intradiol
-
3,4-dioxygenase
- chlorophenolicus
- 2,4,6-trichlorophenols
-
2,4,5-trichlorophenoxyacetic
- gentisate
- naproxen
- 1,2,4-trihydroxybenzene
- 4-chlorophenol
-
nocardioides
-
chlorocatechol
- planococcus
- resorcinol
-
monosubstrate
-
ironiii
- degradation
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
hydroxyquinol 1,2-dioxygenase, cpha-i, 1,2-hqd, cpha-1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
1,2-HQD
Ar 1,2-HQD
cphA-I
HQD
hydroxyquinol 1,2-dioxygenase
hydroxyquinon dioxygenase
-
-
-
-
NpcC
oxygenase, hydroxyquinol 1,2-di-
-
-
-
-
oxygenase, hydroxyquinol di-
-
-
-
-
PdcC
additional information
additional information
cphA-1 encode hydroxyquinol 1,2-dioxygenases. The amino acid sequence of CphA-2 is 78.4% identical to that of CphA-1.
additional information
cphA-2 encodes hydroxyquinol 1,2-dioxygenases. The amino acid sequence of CphA-2 is 78.4% identical to that of CphA-1.
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
hydroxyquinol + O2 = maleylacetate
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
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SYSTEMATIC NAME
IUBMB Comments
benzene-1,2,4-triol:oxygen 1,2-oxidoreductase (decyclizing)
An iron protein. Highly specific; catechol and pyrogallol are acted on at less than 1% of the rate at which hydroxyquinol is oxidized.
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CAS REGISTRY NUMBER
COMMENTARY
91847-14-2
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
catechol + O2
2-hydroxymuconic 6-semialdehyde
extradiol ring cleavage
-
?
6-chlorohydroxyquinol + O2
2-chloromaleylacetate
-
33.5% relative activity of that measured with hydroxyquinol
-
?
6-chlorohydroxyquinol + O2
2-chloromaleylacetate
Azotobacter sp. GP1 / DSM 6428 / ATCC 49806
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33.5% relative activity of that measured with hydroxyquinol
-
?
6-chlorohydroxyquinol + O2
2-chloromaleylacetate
-
-
-
?
benzene-1,2,4-triol + O2
3-hydroxy-cis-cis-muconate
Azotobacter sp. GP1 / DSM 6428 / ATCC 49806
-
-
-
?
benzene-1,2,4-triol + O2
3-hydroxy-cis-cis-muconate
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-
-
-
?
benzene-1,2,4-triol + O2
maleylacetate
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-
maleylacetate, i.e. cis-hexenedioate, is the isomer of 3-hydroxy-cis-cis-muconate
?
benzene-1,2,4-triol + O2
maleylacetate
6.8-fold activity of that for catechol
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-
?
benzene-1,2,4-triol + O2
maleylacetate
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-
maleylacetate, i.e. cis-hexenedioate, is the isomer of 3-hydroxy-cis-cis-muconate
?
benzene-1,2,4-triol + O2
maleylacetate
Azotobacter sp. GP1 / DSM 6428 / ATCC 49806
-
-
maleylacetate, i.e. cis-hexenedioate, is the isomer of 3-hydroxy-cis-cis-muconate
?
benzene-1,2,4-triol + O2
maleylacetate
-
-
maleylacetate, i.e. cis-hexenedioate, is the isomer of 3-hydroxy-cis-cis-muconate
?
benzene-1,2,4-triol + O2
maleylacetate
-
-
maleylacetate, i.e. cis-hexenedioate, is the isomer of 3-hydroxy-cis-cis-muconate
?
benzene-1,2,4-triol + O2
maleylacetate
Fomes pinicola
-
-
maleylacetate, i.e. cis-hexenedioate, is the isomer of 3-hydroxy-cis-cis-muconate
?
benzene-1,2,4-triol + O2
maleylacetate
-
-
maleylacetate, i.e. cis-hexenedioate, is the isomer of 3-hydroxy-cis-cis-muconate
?
benzene-1,2,4-triol + O2
maleylacetate
Lenzites trabea
-
-
maleylacetate, i.e. cis-hexenedioate, is the isomer of 3-hydroxy-cis-cis-muconate
?
benzene-1,2,4-triol + O2
maleylacetate
Poria ambigua
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-
maleylacetate, i.e. cis-hexenedioate, is the isomer of 3-hydroxy-cis-cis-muconate
?
benzene-1,2,4-triol + O2
maleylacetate
-
-
maleylacetate, i.e. cis-hexenedioate, is the isomer of 3-hydroxy-cis-cis-muconate
?
benzene-1,2,4-triol + O2
maleylacetate
-
-
maleylacetate, i.e. cis-hexenedioate, is the isomer of 3-hydroxy-cis-cis-muconate
?
catechol + O2
cis,cis-muconic acid
intradiol ring cleavage
-
?
additional information
?
-
-
when the cells are grown on a mixture of 4-chlorophenol, 4-nitrophenol and phenol, 4-chlorophenol degradation apparently is delayed until 4-nitrophenol is almost completely depleted. Phenol is degraded more slowly than the other compounds and not until 4-nitrophenol and 4-chlorophenol are depleted, despite this being the least toxic compound of the three
-
-
?
additional information
?
-
-
decomposition of aromatic hydrocarbon intermediates by recombinant hydroxyquinol 1,2-dioxygenase. Substrate specificity of Ar 1,2-HQD indicates that the catalytic function of this enzyme is similar to that of the type-II catechol 1,2-dioxygenase (1,2-CTD)
-
-
?
additional information
?
-
decomposition of aromatic hydrocarbon intermediates by recombinant hydroxyquinol 1,2-dioxygenase. Substrate specificity of Ar 1,2-HQD indicates that the catalytic function of this enzyme is similar to that of the type-II catechol 1,2-dioxygenase (1,2-CTD)
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-
?
additional information
?
-
CphA-1 exhibits no activity with 4-chlorocatechol, hydroquinone, or resorcinol
-
-
?
additional information
?
-
CphA-1 exhibits no activity with 4-chlorocatechol, hydroquinone, or resorcinol
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-
?
additional information
?
-
-
CphA-1 exhibits no activity with 4-chlorocatechol, hydroquinone, or resorcinol
-
-
?
additional information
?
-
CphA-2 exhibits no activity with 4-chlorocatechol, hydroquinone, or resorcinol
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-
?
additional information
?
-
CphA-2 exhibits no activity with 4-chlorocatechol, hydroquinone, or resorcinol
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-
?
additional information
?
-
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CphA-2 exhibits no activity with 4-chlorocatechol, hydroquinone, or resorcinol
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-
?
additional information
?
-
Pseudarthrobacter chlorophenolicus A6 / DSM 12829
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when the cells are grown on a mixture of 4-chlorophenol, 4-nitrophenol and phenol, 4-chlorophenol degradation apparently is delayed until 4-nitrophenol is almost completely depleted. Phenol is degraded more slowly than the other compounds and not until 4-nitrophenol and 4-chlorophenol are depleted, despite this being the least toxic compound of the three
-
-
?
additional information
?
-
Pseudarthrobacter chlorophenolicus A6 / DSM 12829
-
decomposition of aromatic hydrocarbon intermediates by recombinant hydroxyquinol 1,2-dioxygenase. Substrate specificity of Ar 1,2-HQD indicates that the catalytic function of this enzyme is similar to that of the type-II catechol 1,2-dioxygenase (1,2-CTD)
-
-
?
additional information
?
-
Pseudarthrobacter chlorophenolicus A6 / DSM 12829
decomposition of aromatic hydrocarbon intermediates by recombinant hydroxyquinol 1,2-dioxygenase. Substrate specificity of Ar 1,2-HQD indicates that the catalytic function of this enzyme is similar to that of the type-II catechol 1,2-dioxygenase (1,2-CTD)
-
-
?
additional information
?
-
-
Pseudomonas sp. PDS-7 is capable of utilizing p-nitrophenol as the sole carbon, nitogen and energy source, concentration up to 80 mg/l
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-
?
additional information
?
-
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PnpG is not active against protocatechuate and gentisate
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-
?
additional information
?
-
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Pseudomonas sp. PDS-7 is capable of utilizing p-nitrophenol as the sole carbon, nitogen and energy source, concentration up to 80 mg/l
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-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
benzene-1,2,4-triol + O2
3-hydroxy-cis-cis-muconate
Azotobacter sp. GP1 / DSM 6428 / ATCC 49806
-
-
-
?
benzene-1,2,4-triol + O2
3-hydroxy-cis-cis-muconate
-
-
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Fe3+
Iron
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE