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The expected taxonomic range for this enzyme is: Candida albicans
Synonyms eapx1, d-erythroascorbate peroxidase, erythroascorbate peroxidase, more
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D-erythroascorbate peroxidase
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erythroascorbate peroxidase
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CaO19.584
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EAPX1
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2 D-ascorbate + H2O2 + 2 H+ = D-ascorbate + D-dehydroascorbate + 2 H2O
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D-ascorbate:hydrogen-peroxide oxidoreductase
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2 D-ascorbate + H2O2 + 2 H+
D-ascorbate + D-dehydroascorbate + 2 H2O
2 D-erythroascorbic acid + H2O2 + 2 H+
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Substrates: - Products: -
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2 L-ascorbate + H2O2 + 2 H+
D-ascorbate + L-dehydroascorbate + 2 H2O
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Substrates: - Products: -
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2 D-ascorbate + H2O2 + 2 H+
D-ascorbate + D-dehydroascorbate + 2 H2O
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Substrates: - Products: -
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2 D-ascorbate + H2O2 + 2 H+
D-ascorbate + D-dehydroascorbate + 2 H2O
Substrates: - Products: -
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2 D-erythroascorbic acid + H2O2 + 2 H+
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Substrates: - Products: -
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UniProt
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Highest Expressing Human Cell Lines
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physiological function
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D-erythroascorbate peroxidase EAPX1 deficiency causes glutathione deprivation, leading to the accumulation of methylglyoxal and reactive oxygen species, and induction of cytochrome c peroxidase CCP1. CCP1/EAPX1 double disruptants show severe growth defects due to D-erythroascorbic acid and glutathione depletion because of pyruvate overaccumulation
physiological function
D-erythroascorbate peroxidase-deficient cells have remarkably increased intracellular reactive oxygen species and methylglyoxal independent of the intracellular D-erythroascorbate content, which leads to activation of catalase-peroxidase and cytochrome c peroxidase, resulting in defects in cell growth, viability, mitochondrial respiration, filamentation and virulence. EAPX1-deficient or EAPX1-overexpressing cells show more sensitivity or resistance against the exogenous H2O2 and menadione, respectively
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CCPR2_CANAL
Candida albicans (strain SC5314 / ATCC MYA-2876)
291
0
32950
Swiss-Prot
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CCP1 deficiency enhances catalase-peroxidase KatG, EAPX1, and glutathione reductase GLR1 transcription
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expression is significantly induced in the presence of H2O2, menadione and diamide
the inactivation of the activities of both Mgd1 and Adh1 triggers the enzyme in non-hyphae-inducing cells
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Kwak, M.K.; Song, S.H.; Ku, M.; Kang, S.O.
Candida albicans erythroascorbate peroxidase regulates intracellular methylglyoxal and reactive oxygen species independently of D-erythroascorbic acid
FEBS Lett.
589
1863-1871
2015
Candida albicans (Q59X94), Candida albicans
brenda
Shin, Y.; Lee, S.; Ku, M.; Kwak, M.K.; Kang, S.O.
Cytochrome c peroxidase regulates intracellular reactive oxygen species and methylglyoxal via enzyme activities of erythroascorbate peroxidase and glutathione-related enzymes in Candida albicans
Int. J. Biochem. Cell Biol.
92
183-201
2017
Candida albicans
brenda
Kang, S.O.; Kwak, M.K.
Methylglyoxal-scavenging enzyme activities trigger erythroascorbate peroxidase and cytochrome c peroxidase in glutathione-depleted Candida albicans
J. Microbiol. Biotechnol.
31
79-91
2021
Candida albicans
brenda
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