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EC Number General Information Commentary Reference
Display the reaction diagram Show all sequences 1.11.1.B10physiological function D-erythroascorbate peroxidase EAPX1 deficiency causes glutathione deprivation, leading to the accumulation of methylglyoxal and reactive oxygen species, and induction of cytochrome c peroxidase CCP1. CCP1/EAPX1 double disruptants show severe growth defects due to D-erythroascorbic acid and glutathione depletion because of pyruvate overaccumulation 742669
Display the reaction diagram Show all sequences 1.11.1.B10physiological function D-erythroascorbate peroxidase-deficient cells have remarkably increased intracellular reactive oxygen species and methylglyoxal independent of the intracellular D-erythroascorbate content, which leads to activation of catalase-peroxidase and cytochrome c peroxidase, resulting in defects in cell growth, viability, mitochondrial respiration, filamentation and virulence. EAPX1-deficient or EAPX1-overexpressing cells show more sensitivity or resistance against the exogenous H2O2 and menadione, respectively 742519
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