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Information on EC 1.1.99.27 - (R)-pantolactone dehydrogenase (flavin)

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IUBMB Comments
High specificity for (R)-pantolactone. Phenazine methosulfate (PMS) can act as acceptor. The enzyme has been studied in the bacterium Nocardia asteroides and shown to be membrane-bound and induced by 1,2-propanediol. The FMN cofactor is non-covalently bound.
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The expected taxonomic range for this enzyme is: Nocardia asteroides
Synonyms
(R)-Pantoyllactone dehydrogenase (flavin), 2-Dehydropantolactone reductase (flavin), 2-Dehydropantoyl-lactone reductase (flavin), dehydrogenase, L-(+)-pantoyllactone, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
(R)-Pantolactone + acceptor = 2-dehydropantolactone + reduced acceptor
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