Ligand (R)-pantolactone

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Basic Ligand Information

Molecular Structure
Picture of (R)-pantolactone (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H10O3
(R)-pantolactone
SERHXTVXHNVDKA-BYPYZUCNSA-N
Synonyms:
(R)-pantoyl lactone, D-(-)-pantoyl lactone, D-pantolactone, D-pantoyl lactone, L-pantolactone, pantoyl lactone
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-dehydropantoyl lactone + NADPH = (R)-pantoyl lactone + NADP+
show the reaction diagram
-
2-dehydropantolactone + NADPH + H+ = (R)-pantolactone + NADP+
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Product in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ketopantoyl lactone + NADPH = (R)-pantolactone + NADP+
show the reaction diagram
-
-
2-dehydropantolactone + NADPH + H+ = (R)-pantolactone + NADP+
show the reaction diagram
-
-
ketopantoyl lactone + NADPH + H+ = pantoyl lactone + NADP+
show the reaction diagram
-
-
pantothenic acid + H2O = beta-alanine + D-pantoyl lactone
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
substrate inhibition of the recombinant isozyme expressed in Escherichia coli at a concentration above 10 mg/ml
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
11.9
-
pH 8.0

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
26.8
-
-
4.3
-
pH 8.0

References & Links

Links to other databases for (R)-pantolactone

ChEBI
PubChem
ChEBI
PubChem