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Information on EC 1.1.1.343 - phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating)

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IUBMB Comments
Highly specific for NAD+. The enzyme catalyses both the oxidation and decarboxylation of 6-phospho-D-gluconate. In the bacterium Methylobacillus flagellatus the enzyme participates in a formaldehyde oxidation pathway . cf. EC 1.1.1.44, phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating).
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The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
6-phospho-gluconate dehydrogenase, ec 1.1.1.44, 6-phospho-d-gluconate:nad+ 2-oxidoreductase (decarboxylating), nad-specific 6-phosphogluconate dehydrogenase, nad+-dependent 6-p-gluconate dehydrogenase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
6-phospho-D-gluconate + NAD+ = D-ribulose 5-phosphate + CO2 + NADH + H+
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