EC Explorer

7.1.1.12

succinate dehydrogenase (electrogenic, proton-motive force generating)

succinate + menaquinone + 2 H⁺_{[side 1]} = fumarate + menaquinol + 2 H⁺_{[side 2]}

succinate:quinone oxidoreductase (electrogenic, proton-motive force generating)

The enzyme is very similar to EC 1.3.5.1, succinate dehydrogenase, but differs by containing two heme molecules (located in the membrane anchor component) in addition to FAD and three iron-sulfur clusters. Unlike EC 1.3.5.1, this enzyme catalyses an electrogenic reaction, enabled by electron-bifurcation via the heme molecules. In the direction of succinate oxidation by menaquinone, which is endergonic, the reaction is driven by the transmembrane electrochemical proton potential. In the direction of fumarate reduction, the electrogenic electron transfer reaction is compensated by transmembrane proton transfer pathway known as the E-pathway, which results in overall electroneutrality.

created 2022