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EC 1.12.1.3 Details

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EC number

1.12.1.3

Accepted name

hydrogen dehydrogenase (NADP⁺)

Reaction

H₂ + NADP⁺ = H⁺ + NADPH

Other name(s)

NADP⁺-linked hydrogenase, NADP⁺-reducing hydrogenase, hydrogenase (ambiguous), hydrogenase I (ambiguous)

Systematic name

hydrogen:NADP⁺ oxidoreductase

CAS registry number

9027-05-8

Comment

The protein from the bacterium Desulfovibrio fructosovorans is an iron-sulfur protein that exclusively functions as a hydrogen dehydrogenase [1], while the enzyme from the archaeon Pyrococcus furiosus is a nickel, iron, iron-sulfur protein, that is part of a heterotetrameric complex where the α and δ subunits function as a hydrogenase while the β and γ subunits function as sulfur reductase (EC 1.12.98.4, sulfhydrogenase). Different from EC 1.12.1.5, hydrogen dehydrogenase [NAD(P)⁺].

History

created 2002, modified 2013

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.12.1 With NAD⁺ or NADP⁺ as acceptor

1.12.1.1 created 1965, deleted 1972

1.12.1.2 hydrogen dehydrogenase

1.12.1.3 hydrogen dehydrogenase (NADP⁺)

1.12.1.4 hydrogenase (NAD⁺, ferredoxin)

1.12.1.5 hydrogen dehydrogenase [NAD(P)⁺]

1.12.2 With a cytochrome as acceptor

1.12.5 With a quinone or similar compound as acceptor

1.12.7 With an iron-sulfur protein as acceptor

1.12.98 With other, known, physiological acceptors

1.12.99 With unknown physiological acceptors

1.12.99.1 created 1989, deleted 2002

1.12.99.2 created 1992, deleted 2002

1.12.99.3 created 1999, deleted 2002

1.12.99.4 created 1999, deleted 2002

1.12.99.5 created 1999, deleted 2001

1.12.99.6 hydrogenase (acceptor)

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)