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Information on EC 1.12.1.5 - hydrogen dehydrogenase [NAD(P)+]

for references in articles please use BRENDA:EC1.12.1.5

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IUBMB Comments

A nickel, iron, iron-sulfur protein. The enzyme from the archaeon Pyrococcus furiosus is part of a heterotetrameric complex where the α and δ subunits function as a hydrogenase while the β and γ subunits function as sulfur reductase (EC 1.12.98.4, sulfhydrogenase). Different from EC 1.12.1.3, hydrogen dehydrogenase (NADP+).

The expected taxonomic range for this enzyme is: Archaea, Bacteria
Reaction Schemes

Synonyms
H-II, hydrogenase II, SHI, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
H2 + NAD(P)+ = H+ + NAD(P)H
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
Highest Expressing Human Cell Lines
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