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Information on EC 1.12.1.5 - hydrogen dehydrogenase [NAD(P)+]

for references in articles please use BRENDA:EC1.12.1.5
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IUBMB Comments
A nickel, iron, iron-sulfur protein. The enzyme from the archaeon Pyrococcus furiosus is part of a heterotetrameric complex where the alpha and delta subunits function as a hydrogenase while the beta and gamma subunits function as sulfur reductase (EC 1.12.98.4, sulfhydrogenase). Different from EC 1.12.1.3, hydrogen dehydrogenase (NADP+).
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The expected taxonomic range for this enzyme is: Archaea, Bacteria
Reaction Schemes
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H2
+
NAD(P)+
=
H+
+
NAD(P)H
+
=
+
Synonyms
H-II, hydrogenase II, SHI, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
H2 + NAD(P)+ = H+ + NAD(P)H
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PATHWAY SOURCE
PATHWAYS
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