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EC 1.11.1.23 Details
show Brenda entryEC number
1.11.1.23
Accepted name
(S)-2-hydroxypropylphosphonic acid epoxidase
Reaction
(S)-2-hydroxypropylphosphonate + H2O2 = (1R,2S)-1,2-epoxypropylphosphonate + 2 H2O
Other name(s)
HPP epoxidase,
HppE,
2-hydroxypropylphosphonic acid epoxidase,
Fom4,
(S)-2-hydroxypropylphosphonate epoxidase
Systematic name
(S)-2-hydroxypropylphosphonate:hydrogen-peroxide epoxidase
Comment
This is the last enzyme in the biosynthetic pathway of fosfomycin, a broad-spectrum antibiotic produced by certain Streptomyces species. Contains non heme iron that forms a iron(IV)-oxo (ferryl) complex with hydrogen peroxide, which functions as a proton abstractor from the substrate [7].
History
created 2011 as EC 1.14.19.7, transferred 2014 to EC 1.11.1.23
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.11.1.1 NADH peroxidase
