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Information on EC 1.11.1.23 - (S)-2-hydroxypropylphosphonic acid epoxidase

for references in articles please use BRENDA:EC1.11.1.23
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IUBMB Comments
This is the last enzyme in the biosynthetic pathway of fosfomycin, a broad-spectrum antibiotic produced by certain Streptomyces species. Contains non heme iron that forms a iron(IV)-oxo (ferryl) complex with hydrogen peroxide, which functions as a proton abstractor from the substrate .
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
hpp epoxidase, ps-hppe, 2-hydroxypropylphosphonic acid epoxidase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(S)-2-hydroxypropylphosphonate + H2O2 = (1R,2S)-1,2-epoxypropylphosphonate + 2 H2O
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