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EC 1.1.5.2 Details

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EC number

1.1.5.2

Accepted name

glucose 1-dehydrogenase (PQQ, quinone)

Reaction

D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol

Other name(s)

quinoprotein glucose dehydrogenase, membrane-bound glucose dehydrogenase, mGDH, glucose dehydrogenase (PQQ-dependent), glucose dehydrogenase (pyrroloquinoline-quinone), quinoprotein D-glucose dehydrogenase

Systematic name

D-glucose:ubiquinone oxidoreductase

CAS registry number

81669-60-5

Comment

Integral membrane protein containing PQQ as prosthetic group. It also contains bound ubiquinone and Mg²⁺ or Ca²⁺. Electron acceptor is membrane ubiquinone but usually assayed with phenazine methosulfate. Like in all other quinoprotein alcohol dehydrogenases the catalytic domain has an 8-bladed propeller structure. It occurs in a wide range of bacteria. Catalyses a direct oxidation of the pyranose form of D-glucose to the lactone and thence to D-gluconate in the periplasm. Oxidizes other monosaccharides including the pyranose forms of pentoses.

History

created 1982 as EC 1.1.99.17, transferred 2003 to EC 1.1.5.2, modified 2010

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.2 With a cytochrome as acceptor

1.1.3 With oxygen as acceptor

1.1.4 With a disulfide as acceptor

1.1.5 With a quinone or similar compound as acceptor

1.1.5.1 created 1983, deleted 2002

1.1.5.2 glucose 1-dehydrogenase (PQQ, quinone)

1.1.5.3 glycerol-3-phosphate dehydrogenase

1.1.5.4 malate dehydrogenase (quinone)

1.1.5.5 alcohol dehydrogenase (quinone)

1.1.5.6 formate dehydrogenase-N

1.1.5.7 cyclic alcohol dehydrogenase (quinone)

1.1.5.8 quinate/shikimate dehydrogenase (quinone)

1.1.5.9 glucose 1-dehydrogenase (FAD, quinone)

1.1.5.10 D-2-hydroxyacid dehydrogenase (quinone)

1.1.5.11 1-butanol dehydrogenase (quinone)

1.1.5.12 D-lactate dehydrogenase (quinone)

1.1.5.13 (S)-2-hydroxyglutarate dehydrogenase

1.1.5.14 fructose 5-dehydrogenase

1.1.7 With an iron-sulfur protein as acceptor

1.1.9 With a copper protein as acceptor

1.1.98 With other, known, physiological acceptors

1.1.99 With unknown physiological acceptors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.6.1 With NAD⁺ or NADP⁺ as acceptor

1.6.2 With a heme protein as acceptor

1.6.3 With oxygen as acceptor

1.6.4 With a disulfide as acceptor (deleted sub-subclass)

1.6.5 With a quinone or similar compound as acceptor

1.6.6 With a nitrogenous group as acceptor

1.6.7 With an iron-sulfur protein as acceptor (deleted sub-subclass)

1.6.8 With a flavin as acceptor (deleted sub-subclass)

1.6.99 With unknown physiological acceptors

1.6.99.1 NADPH dehydrogenase

1.6.99.2 created 1961 as EC 1.6.5.2, transferred 1965 to EC 1.6.99.2, deleted 2005

1.6.99.3 NADH dehydrogenase

1.6.99.4 created 1965, deleted 1972

1.6.99.5 NADH dehydrogenase (quinone)

1.6.99.6 NADPH dehydrogenase (quinone)

1.6.99.7 created 1972, modified 1981 (EC 1.6.99.10 created 1978, incorporated 1981), deleted 2003

1.6.99.8 created 1972, deleted 2002

1.6.99.9 created 1972, deleted 2002

1.6.99.10 created 1978, deleted 1981

1.6.99.11 created 1989, deleted 2002

1.6.99.12 created 1989, deleted 2002

1.6.99.13 created 1992, deleted 2002

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)