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EC 2.7.11.21 Details
EC number
2.7.11.21
Accepted name
polo kinase
Reaction
ATP + a protein = ADP + a phosphoprotein
Other name(s)
Cdc5, Cdc5p, Plk, PLK, Plk1, Plo1, POLO kinase, polo serine-threonine kinase, polo-like kinase, polo-like kinase 1, serine/threonine-specific Drosophila kinase polo, STK21
Systematic name
ATP:protein phosphotransferase (spindle-pole-dependent)
CAS registry number
149433-93-2
Comment
The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein [2].
History
created 2005 (EC 2.7.1.37 part-incorporated 2005)
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EC Tree
1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.2 Acting on the aldehyde or oxo group of donors
1.3 Acting on the CH-CH group of donors
1.4 Acting on the CH-NH2 group of donors
1.5 Acting on the CH-NH group of donors
1.6 Acting on NADH or NADPH
1.7 Acting on other nitrogenous compounds as donors
1.8 Acting on a sulfur group of donors
1.9 Acting on a heme group of donors
1.10 Acting on diphenols and related substances as donors
1.11 Acting on a peroxide as acceptor
1.12 Acting on hydrogen as donor
1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.15 Acting on superoxide as acceptor
1.16 Oxidizing metal ions
1.17 Acting on CH or CH2 groups
1.18 Acting on iron-sulfur proteins as donors
1.19 Acting on reduced flavodoxin as donor
1.20 Acting on phosphorus or arsenic in donors
1.21 Catalysing the reaction X-H + Y-H = X-Y
1.22 Acting on halogen in donors
1.23 Reducing C-O-C group as acceptor
1.23.1 With NADH or NADPH as donor
1.23.5 With a quinone or similar compound as acceptor
1.97 Other oxidoreductases
1.98 Enzymes using H2 as reductant (deleted subclass)
1.99 Other enzymes using O2 as oxidant (deleted subclass)
2 Transferases
2.1 Transferring one-carbon groups
2.2 Transferring aldehyde or ketonic groups
2.3 Acyltransferases
2.4 Glycosyltransferases
2.5 Transferring alkyl or aryl groups, other than methyl groups
2.6 Transferring nitrogenous groups
2.7 Transferring phosphorus-containing groups
2.7.1 Phosphotransferases with an alcohol group as acceptor
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.3 Phosphotransferases with a nitrogenous group as acceptor
2.7.4 Phosphotransferases with a phosphate group as acceptor
2.7.5 Phosphotransferases with regeneration of donors, apparently catalysing intramolecular transfers (deleted sub-subclass)
2.7.6 Diphosphotransferases
2.7.7 Nucleotidyltransferases
2.7.8 Transferases for other substituted phosphate groups
2.7.9 Phosphotransferases with paired acceptors
2.7.10 Protein-tyrosine kinases
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
2.7.11.2 [pyruvate dehydrogenase (acetyl-transferring)] kinase
2.7.11.3 dephospho-[reductase kinase] kinase
2.7.11.4 [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase
2.7.11.5 [isocitrate dehydrogenase (NADP+)] kinase
2.7.11.6 [tyrosine 3-monooxygenase] kinase
2.7.11.7 myosin-heavy-chain kinase
2.7.11.8 Fas-activated serine/threonine kinase
2.7.11.9 Goodpasture-antigen-binding protein kinase
2.7.11.10 IκB kinase
2.7.11.11 cAMP-dependent protein kinase
2.7.11.12 cGMP-dependent protein kinase
2.7.11.13 protein kinase C
2.7.11.14 rhodopsin kinase
2.7.11.15 β-adrenergic-receptor kinase
2.7.11.16 G-protein-coupled receptor kinase
2.7.11.17 Ca2+/calmodulin-dependent protein kinase
2.7.11.18 myosin-light-chain kinase
2.7.11.19 phosphorylase kinase
2.7.11.20 elongation factor 2 kinase
2.7.11.21 polo kinase
2.7.11.22 cyclin-dependent kinase
2.7.11.23 [RNA-polymerase]-subunit kinase
2.7.11.24 mitogen-activated protein kinase
2.7.11.25 mitogen-activated protein kinase kinase kinase
2.7.11.26 tau-protein kinase
2.7.11.27 [acetyl-CoA carboxylase] kinase
2.7.11.28 tropomyosin kinase
2.7.11.29 low-density-lipoprotein receptor kinase
2.7.11.30 receptor protein serine/threonine kinase
2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase
2.7.11.32 [pyruvate, phosphate dikinase] kinase
2.7.11.33 [pyruvate, water dikinase] kinase
2.7.11.34 NEK6-subfamily protein kinase
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.13 Protein-histidine kinases
2.7.14 Protein-arginine kinases
2.7.99 Other protein kinases
2.8 Transferring sulfur-containing groups
2.9 Transferring selenium-containing groups
2.10 Transferring molybdenum- or tungsten-containing groups
3 Hydrolases
4 Lyases
5 Isomerases
6 Ligases
7 Translocases