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EC 2.7.11.14 Details
EC number
2.7.11.14
Accepted name
rhodopsin kinase
Reaction
ATP + rhodopsin = ADP + phosphorhodopsin
Other name(s)
cone opsin kinase,
G-protein-coupled receptor kinase 1,
GPCR kinase 1,
GRK1,
GRK7,
opsin kinase,
opsin kinase (phosphorylating),
rhodopsin kinase (phosphorylating),
RK,
STK14
Systematic name
ATP:rhodopsin phosphotransferase
CAS registry number
54004-64-7
Comment
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the bleached or activated form of rhodopsin; also phosphorylates the β-adrenergic receptor, but more slowly. Does not act on casein, histones or phosphvitin. Inhibited by Zn2+ and digitonin (cf. EC 2.7.11.15, β-adrenergic-receptor kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).
History
created 1989 as EC 2.7.1.125 (EC 2.7.1.97 created 1978, incorporated 1992), transferred 2005 to EC 2.7.11.14
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