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EC 2.6.1.93 Details

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EC number

2.6.1.93

Accepted name

neamine transaminase

Reaction

neamine + 2-oxoglutarate = 6′-dehydroparomamine + L-glutamate

Other name(s)

glutamate—6′-dehydroparomamine aminotransferase, btrB (gene name), neoN (gene name), kacL (gene name)

Systematic name

neamine:2-oxoglutarate aminotransferase

Comment

The reaction occurs in vivo in the opposite direction. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin B, butirosin, neomycin and ribostamycin. Works in combination with EC 1.1.3.43, paromamine 6-oxidase, to replace the 6′-hydroxy group of paromamine with an amino group. The enzyme from the bacterium Streptomyces kanamyceticus can also catalyse EC 2.6.1.94, 2′-deamino-2′-hydroxyneamine transaminase, which leads to production of kanamycin A [3]. The enzyme from the bacterium Streptomyces fradiae can also catalyse EC 2.6.1.95, leading to production of neomycin C [2].

History

created 2012

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.11.1 Peroxidases

1.11.2 Peroxygenases

1.12 Acting on hydrogen as donor

1.12.1 With NAD⁺ or NADP⁺ as acceptor

1.12.2 With a cytochrome as acceptor

1.12.5 With a quinone or similar compound as acceptor

1.12.7 With an iron-sulfur protein as acceptor

1.12.98 With other, known, physiological acceptors

1.12.99 With unknown physiological acceptors

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

2.1 Transferring one-carbon groups

2.2 Transferring aldehyde or ketonic groups

2.3 Acyltransferases

2.4 Glycosyltransferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.6 Transferring nitrogenous groups

2.6.1 Transaminases

2.6.1.1 aspartate transaminase

2.6.1.2 alanine transaminase

2.6.1.3 cysteine transaminase

2.6.1.4 glycine transaminase

2.6.1.5 tyrosine transaminase

2.6.1.6 leucine transaminase

2.6.1.7 kynurenine—oxoglutarate transaminase

2.6.1.8 2,5-diaminovalerate transaminase

2.6.1.9 histidinol-phosphate transaminase

2.6.1.10 created 1961, deleted 1972

2.6.1.11 acetylornithine transaminase

2.6.1.12 alanine—oxo-acid transaminase

2.6.1.13 ornithine aminotransferase

2.6.1.14 asparagine—oxo-acid transaminase

2.6.1.15 glutamine—pyruvate transaminase

2.6.1.16 glutamine—fructose-6-phosphate transaminase (isomerizing)

2.6.1.17 succinyldiaminopimelate transaminase

2.6.1.18 β-alanine—pyruvate transaminase

2.6.1.19 4-aminobutyrate—2-oxoglutarate transaminase

2.6.1.20 created 1965, deleted 1972

2.6.1.21 D-amino-acid transaminase

2.6.1.22 (S)-3-amino-2-methylpropionate transaminase

2.6.1.23 4-hydroxyglutamate transaminase

2.6.1.24 diiodotyrosine transaminase

2.6.1.25 created 1972, deleted 1984

2.6.1.26 thyroid-hormone transaminase

2.6.1.27 tryptophan transaminase

2.6.1.28 tryptophan—phenylpyruvate transaminase

2.6.1.29 diamine transaminase

2.6.1.30 pyridoxamine—pyruvate transaminase

2.6.1.31 pyridoxamine—oxaloacetate transaminase

2.6.1.32 valine—3-methyl-2-oxovalerate transaminase

2.6.1.33 dTDP-4-amino-4,6-dideoxy-D-glucose transaminase

2.6.1.34 UDP-N-acetylbacillosamine transaminase

2.6.1.35 glycine—oxaloacetate transaminase

2.6.1.36 L-lysine 6-transaminase

2.6.1.37 2-aminoethylphosphonate—pyruvate transaminase

2.6.1.38 histidine transaminase

2.6.1.39 2-aminoadipate transaminase

2.6.1.40 (R)-3-amino-2-methylpropionate—pyruvate transaminase

2.6.1.41 D-methionine—pyruvate transaminase

2.6.1.42 branched-chain-amino-acid transaminase

2.6.1.43 aminolevulinate transaminase

2.6.1.44 alanine—glyoxylate transaminase

2.6.1.45 serine—glyoxylate transaminase

2.6.1.46 diaminobutyrate—pyruvate transaminase

2.6.1.47 alanine—oxomalonate transaminase

2.6.1.48 5-aminovalerate transaminase

2.6.1.49 dihydroxyphenylalanine transaminase

2.6.1.50 glutamine—scyllo-inositol transaminase

2.6.1.51 serine—pyruvate transaminase

2.6.1.52 phosphoserine transaminase

2.6.1.53 created 1972, deleted 1976

2.6.1.54 pyridoxamine-phosphate transaminase

2.6.1.55 taurine—2-oxoglutarate transaminase

2.6.1.56 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase

2.6.1.57 aromatic-amino-acid transaminase

2.6.1.58 phenylalanine(histidine) transaminase

2.6.1.59 dTDP-4-amino-4,6-dideoxygalactose transaminase

2.6.1.60 aromatic-amino-acid—glyoxylate transaminase

2.6.1.61 created 1982, deleted 2004

2.6.1.62 adenosylmethionine—8-amino-7-oxononanoate transaminase

2.6.1.63 kynurenine—glyoxylate transaminase

2.6.1.64 glutamine—phenylpyruvate transaminase

2.6.1.65 N⁶-acetyl-β-lysine transaminase

2.6.1.66 valine—pyruvate transaminase

2.6.1.67 2-aminohexanoate transaminase

2.6.1.68 ornithine(lysine) transaminase

2.6.1.69 created 1989, deleted 2004

2.6.1.70 aspartate—phenylpyruvate transaminase

2.6.1.71 lysine—pyruvate 6-transaminase

2.6.1.72 D-4-hydroxyphenylglycine transaminase

2.6.1.73 methionine—glyoxylate transaminase

2.6.1.74 cephalosporin-C transaminase

2.6.1.75 cysteine-conjugate transaminase

2.6.1.76 diaminobutyrate—2-oxoglutarate transaminase

2.6.1.77 taurine—pyruvate aminotransferase

2.6.1.78 aspartate—prephenate aminotransferase

2.6.1.79 glutamate—prephenate aminotransferase

2.6.1.80 nicotianamine aminotransferase

2.6.1.81 succinylornithine transaminase

2.6.1.82 putrescine—2-oxoglutarate transaminase

2.6.1.83 LL-diaminopimelate aminotransferase

2.6.1.84 arginine—pyruvate transaminase

2.6.1.85 aminodeoxychorismate synthase

2.6.1.86 2-amino-4-deoxychorismate synthase

2.6.1.87 UDP-4-amino-4-deoxy-L-arabinose aminotransferase

2.6.1.88 methionine transaminase

2.6.1.89 dTDP-3-amino-3,6-dideoxy-α-D-glucopyranose transaminase

2.6.1.90 dTDP-3-amino-3,6-dideoxy-α-D-galactopyranose transaminase

2.6.1.91 UDP-4-amino-4,6-dideoxy-N-acetyl-α-D-glucosamine transaminase

2.6.1.92 UDP-4-amino-4,6-dideoxy-N-acetyl-β-L-altrosamine transaminase

2.6.1.93 neamine transaminase

2.6.1.94 2′-deamino-2′-hydroxyneamine transaminase

2.6.1.95 neomycin C transaminase

2.6.1.96 4-aminobutyrate—pyruvate transaminase

2.6.1.97 archaeosine synthase

2.6.1.98 UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase

2.6.1.99 L-tryptophan—pyruvate aminotransferase

2.6.1.100 L-glutamine:2-deoxy-scyllo-inosose aminotransferase

2.6.1.101 L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase

2.6.1.102 GDP-perosamine synthase

2.6.1.103 (S)-3,5-dihydroxyphenylglycine transaminase

2.6.1.104 3-dehydro-glucose-6-phosphate—glutamate transaminase

2.6.1.105 lysine—8-amino-7-oxononanoate transaminase

2.6.1.106 dTDP-3-amino-3,4,6-trideoxy-α-D-glucose transaminase

2.6.1.107 β-methylphenylalanine transaminase

2.6.1.108 (5-formylfuran-3-yl)methyl phosphate transaminase

2.6.1.109 8-amino-3,8-dideoxy-α-D-manno-octulosonate transaminase

2.6.1.110 dTDP-4-dehydro-2,3,6-trideoxy-D-glucose 4-aminotransferase

2.6.1.111 3-aminobutanoyl-CoA transaminase

2.6.1.112 (S)-ureidoglycine—glyoxylate transaminase

2.6.1.113 putrescine—pyruvate transaminase

2.6.1.114 8-demethyl-8-aminoriboflavin-5′-phosphate synthase

2.6.1.115 5-hydroxydodecatetraenal 1-aminotransferase

2.6.1.116 6-aminohexanoate aminotransferase

2.6.1.117 L-glutamine—4-(methylsulfanyl)-2-oxobutanoate aminotransferase

2.6.1.118 [amino-group carrier protein]-γ-(L-lysyl)-L-glutamate aminotransferase

2.6.1.119 vanillin aminotransferase

2.6.1.120 β-alanine—2-oxoglutarate transaminase

2.6.1.121 8-amino-7-oxononanoate carboxylating dehydrogenase

2.6.1.122 UDP-N-acetyl-3-dehydro-α-D-glucosamine 3-aminotranferase

2.6.1.123 4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming)

2.6.1.124 [amino-group carrier protein]-γ-(L-ornithyl)-L-glutamate aminotransferase

2.6.2 Amidinotransferases (deleted sub-subclass)

2.6.3 Oximinotransferases

2.6.99 Transferring other nitrogenous groups

2.7 Transferring phosphorus-containing groups

2.8 Transferring sulfur-containing groups

2.9 Transferring selenium-containing groups

2.10 Transferring molybdenum- or tungsten-containing groups

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Release 2023.1 (January 2023)