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Information on EC - neomycin C transaminase

for references in articles please use BRENDA:EC2.6.1.95
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EC Tree
     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
       neomycin C transaminase
IUBMB Comments
The reaction occurs in vivo in the opposite direction. Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. Works in combination with EC, 6'''-hydroxyneomycin C oxidase, to replace the 6'''-hydroxy group of 6'''-deamino-6'''-hydroxyneomycin C with an amino group. The enzyme, characterized from the bacterium Streptomyces fradiae, can also catalyse EC, neamine transaminase.
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The enzyme appears in viruses and cellular organisms
6'-oxoglucosaminyl:L-glutamate aminotransferase, Neo-18, neoB, neoN, more
neomycin C + 2-oxoglutarate = 6'''-deamino-6'''-oxoneomycin C + L-glutamate
show the reaction diagram
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