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EC 2.1.3.1 Details

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EC number

2.1.3.1

Accepted name

methylmalonyl-CoA carboxytransferase

Reaction

(S)-methylmalonyl-CoA + pyruvate = propanoyl-CoA + oxaloacetate

Other name(s)

transcarboxylase, methylmalonyl coenzyme A carboxyltransferase, methylmalonyl-CoA transcarboxylase, oxalacetic transcarboxylase, methylmalonyl-CoA carboxyltransferase, (S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxyltransferase, (S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxytransferase carboxytransferase [incorrect]

Systematic name

(S)-methylmalonyl-CoA:pyruvate carboxytransferase

CAS registry number

9029-86-1

Comment

A biotinyl-protein, containing cobalt and zinc. The enzyme, described from the bacterium Propionibacterium shermanii, is unique among the biotin-dependent enzymes in that it catalyses carboxyl transfer between two organic molecules, utilizing two separate carboxyltransferase domains. The enzyme is a very large complex, consisting of a hexameric central core of 12S subunits surrounded by six 5S subunit dimers, each connected to the central core by twelve 1.3S biotin carrier subunits.

History

created 1961

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.12.1 With NAD⁺ or NADP⁺ as acceptor

1.12.2 With a cytochrome as acceptor

1.12.5 With a quinone or similar compound as acceptor

1.12.7 With an iron-sulfur protein as acceptor

1.12.98 With other, known, physiological acceptors

1.12.99 With unknown physiological acceptors

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.2 Hydroxymethyl-, formyl- and related transferases

2.1.3 Carboxy- and carbamoyltransferases

2.1.3.1 methylmalonyl-CoA carboxytransferase

2.1.3.2 aspartate carbamoyltransferase

2.1.3.3 ornithine carbamoyltransferase

2.1.3.4 created 1965, deleted 1972

2.1.3.5 oxamate carbamoyltransferase

2.1.3.6 putrescine carbamoyltransferase

2.1.3.7 3-hydroxymethylcephem carbamoyltransferase

2.1.3.8 lysine carbamoyltransferase

2.1.3.9 N-acetylornithine carbamoyltransferase

2.1.3.10 malonyl-S-ACP:biotin-protein carboxyltransferase

2.1.3.11 N-succinylornithine carbamoyltransferase

2.1.3.12 decarbamoylnovobiocin carbamoyltransferase

2.1.3.13 ATP carbamoyltransferase

2.1.3.14 tobramycin carbamoyltransferase

2.1.3.15 acetyl-CoA carboxytransferase

2.1.3.16 ureidoglycine carbamoyltransferase

2.1.4 Amidinotransferases

2.1.5 Methylenetransferases

2.2 Transferring aldehyde or ketonic groups

2.3 Acyltransferases

2.4 Glycosyltransferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.6 Transferring nitrogenous groups

2.7 Transferring phosphorus-containing groups

2.8 Transferring sulfur-containing groups

2.9 Transferring selenium-containing groups

2.10 Transferring molybdenum- or tungsten-containing groups